Actively Recruiting
Randomized Study Comparing Bariatric Surgery and Lifestyle Therapy for Severe NASH With Advanced Liver Fibrosis in Adults
Led by University Hospital, Lille · Updated on 2026-04-22
100
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of bariatric surgery compared to standard medical treatment in obese patients with nonalcoholic steatohepatitis NASH complicated by advanced liver fibrosis grades F3 and F4. This study aims to show whether bariatric surgery leads to the disappearance of NASH without worsening fibrosis in patients with a body mass index BMI between 30 and 35 kgm for F3 fibrosis, and between 30 and 50 kgm for F4 fibrosis. The trial is open-label and randomized, designed to compare surgical intervention with lifestyle therapy.
CONDITIONS
Brief Title
A Randomized Controlled Study Evaluating Bariatric Surgery as a Treatment for Severe NASH With Advanced Liver Fibrosis in Non-severe Obese Patients
Research Team
P
Philippe Mathurin, MD,PhD
G
Guillaume Lassailly, MD
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