Study Comparing Genicular Artery Embolization Using Nexsphere-F to Steroid Injection for Treating Knee Osteoarthritis Pain

What this Trial Is About

This research is a multi-center, prospective, randomized trial comparing genicular artery embolization GAE using Nexsphere-F with intra-articular corticosteroid injection for patients experiencing knee osteoarthritis pain. The study aims to evaluate and compare these two treatments in managing localized knee pain associated with osteoarthritis. The trial is sponsored by North American Science Associates Ltd. and does not involve blinding of participants or researchers. Participants will be randomly assigned to one of two groups one receiving genicular artery embolization, a device-based procedure, and the other receiving corticosteroid injections directly into the knee joint. These interventions are being assessed to understand their impact on knee osteoarthritis symptoms. The treatment phase and follow-up include multiple assessments over a one-year period. During the study, participants will undergo evaluations using the Western Ontario and McMaster Universities Osteoarthritis Index WOMAC at 6, 9, and 12 months post-treatment to measure pain, stiffness, and physical function. Researchers will also monitor serious adverse events at treatment and follow-up visits to ensure safety. The total participation duration includes treatment and up to 12 months of post-treatment monitoring for outcomes and safety.

Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain