Actively Recruiting
Randomized Controlled Study of Programmed Weaning From Noninvasive Mechanical Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Led by Peking University Third Hospital · Updated on 2025-01-22
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a programmed withdrawal process for noninvasive ventilation to reduce the duration of mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD). This single-center, prospective, randomized controlled study compares a programmed weaning approach to traditional withdrawal methods in patients admitted to the intensive care unit with acute COPD exacerbations. The study aims to better manage ventilation withdrawal and improve patient outcomes. The study involves two groups: the programmed withdrawal unit and the traditional withdrawal unit. In the programmed group, patients receive daily morning arterial blood gas analysis, followed by scheduled reductions in noninvasive ventilation time over several days if blood gas results show compensation of respiratory acidosis. The traditional group receives ventilation weaning based on the attending physician's decision according to the patient's condition. If noninvasive ventilation fails, invasive mechanical ventilation is provided. Participants will be monitored for complete removal of noninvasive ventilation, time spent in the intensive care unit, total hospital stay length, and ventilation failure rates. Assessments include daily arterial blood gas measurements and clinical observations. The study measures the time until complete ventilation withdrawal, averaging 11 days, with follow-up lasting through hospital discharge, approximately 20 days. Safety and treatment success will be closely tracked during this period.
CONDITIONS
Brief Title
Randomized Controlled Study of Programmed Weaning From NIV for AECOPD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with acute exacerbation of chronic obstructive pulmonary disease showing respiratory acidosis with pH between 7.20 and 7.35
- Patients who have received noninvasive mechanical ventilation and tolerated it well
You will not qualify if you...
- Younger than 40 years old
- Pregnant women
- Positive for human immunodeficiency virus (HIV) antibody
- Hemodynamic instability
- Disagreement with mechanical ventilation for endotracheal intubation and cardiopulmonary resuscitation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Approximately 11 days until complete evacuation of non-invasive ventilation
Participants receive programmed weaning from noninvasive mechanical ventilation or traditional withdrawal as decided by the attending physician while admitted in the intensive care unit for acute exacerbation of chronic obstructive pulmonary disease.
Daily morning visits for arterial blood gas analysis and ventilation adjustments
Duration - Up to 20 days including ICU and hospital stay
Participants are monitored in the hospital for outcomes including length of stay, ICU time, and ventilation failure after non-invasive ventilation ends.
Regular assessments during hospital stay
Trial Site Locations
Total: 1 location
1
Peking University Third Hospita
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
Research Team
F
Feifan Zhao
Q
Qingtao Zhou
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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