Diabetes Testing Immediately Postpartum After Gestational Diabetes Mellitus: A Randomized Controlled Trial.
Christine Field, William A Grobman, Devra Mast...
https://pubmed.ncbi.nlm.nih.gov/41842598/Actively Recruiting
Led by Ohio State University · Updated on 2025-11-24
104
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating postpartum diabetes screening methods and cardiovascular health counseling for individuals who experienced gestational diabetes during pregnancy. The study compares immediate inpatient postpartum oral glucose tolerance testing OGTT before hospital discharge to the current standard outpatient OGTT performed 4-12 weeks after delivery. Additionally, the study explores patient perspectives on postpartum cardiovascular health counseling and risk reduction, including social and structural factors that affect health outcomes. This research is conducted to address the increased risk of type 2 diabetes and cardiovascular disease in this population and to improve postpartum care. The trial includes two study groups one receiving an immediate inpatient 2-hour OGTT before discharge, and the other receiving the standard 4-12 week outpatient OGTT. Eligible participants are individuals aged 18 or older, diagnosed with gestational diabetes during pregnancy, and receiving prenatal and postpartum care at the study site. A follow-up phase involves surveys and qualitative assessments between 12 and 24 months postpartum to evaluate barriers and facilitators of cardiovascular health counseling and wellness interventions. Participants will undergo diabetes screening either immediately postpartum or during the standard postpartum visit, with data collected on screening rates up to 12 weeks after delivery. Patient-reported outcomes on cardiovascular health counseling will be gathered within 12 months postpartum, while patient perspectives on postpartum interventions will be assessed between 12 and 24 months postpartum. The study measures include diabetes screening rates, cardiovascular counseling experiences, lifestyle changes, primary care visits, and diabetes treatment satisfaction. This research helps identify ways to improve postpartum screening and cardiovascular health management for individuals with gestational diabetes.
CONDITIONS
A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE
K
Kartik Venkatesh, MD, PhD
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Ohio State University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Immediate inpatient OGTT | Standard outpatient OGTT | Guideline‑recommended OGTT (4–12 weeks) |
|---|---|---|---|
| What it is | A diagnostic 2‑hour oral glucose tolerance test performed before hospital discharge after delivery | A diagnostic 2‑hour oral glucose tolerance test scheduled 4–12 weeks after delivery in an outpatient setting | Postpartum OGTT is recommended between 4 and 12 weeks postpartum per current ADA Standards of Care |
| Role in trial | Investigational diagnostic timing being tested against standard care | Control group receiving usual outpatient timing of OGTT | Represents guideline‑recommended practice rather than a trial arm |
| Primary purpose | To increase rate and timeliness of postpartum diabetes screening | Standard practice to assess glucose tolerance during early postpartum period | Early postpartum assessment to detect prediabetes or type 2 diabetes |
| How it is performed | Inpatient 2‑hour OGTT conducted before hospital discharge | Outpatient 2‑hour OGTT scheduled between 4 and 12 weeks postpartum | OGTT performed in outpatient setting between 4 and 12 weeks after delivery |
| Evidence status | Efficacy under investigation via randomized trial; screening rates being measured | Established strategy with widespread use but variable completion rates | Guideline‑endorsed, evidence‑based timing with support from professional standards |
| Important risks | Possible discomfort or nausea during OGTT; gastric bypass patients may not tolerate test | Similar OGTT risks applied on outpatient basis | Risks are those standard for OGTT testing |
| Important limitations | May not be feasible for all patients before discharge; gastric bypass excluded | Outpatient follow‑up often missed leading to low screening completion rates | Recommended timing may delay diagnosis if follow‑up is not completed |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
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Duration - During delivery hospital admission
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From delivery to up to 12 weeks postpartum
Participants undergo diabetes screening either immediately postpartum with a 2-hour oral glucose tolerance test (OGTT) before hospital discharge or the standard 4-12 week outpatient postpartum OGTT.
1 to 2 visits depending on assigned group (immediate inpatient or outpatient OGTT)
Duration - Within 12 to 24 months postpartum
Participants provide feedback on postpartum cardiovascular health counseling and share perspectives on interventions to improve future maternal cardiovascular health after gestational diabetes.
Follow-up contacts within 12 to 24 months postpartum
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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Christine Field, William A Grobman, Devra Mast...
https://pubmed.ncbi.nlm.nih.gov/41842598/Ohio State University
Lead Sponsor