Actively Recruiting
A Randomized Controlled Trial of Inhaled Tranexamic Acid for the Treatment of Pulmonary Hemorrhage in Cancer Patients
Led by M.D. Anderson Cancer Center · Updated on 2026-01-14
60
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a drug study that will examine if inhaled tranexamic acid can improve mortality in patients with cancer-related pulmonary hemorrhage and respiratory failure as compared to usual care.
CONDITIONS
Official Title
A Randomized Controlled Trial of Inhaled Tranexamic Acid for the Treatment of Pulmonary Hemorrhage in Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- Diagnosed hematological malignancy
- Currently receiving mechanical ventilation
- Evidence of pulmonary hemorrhage through bloody secretions upon endotracheal suctioning or diffuse alveolar hemorrhage seen by bronchoscopy
- Signed informed consent by patient or legally authorized representative if patient lacks decision-making capacity
You will not qualify if you...
- Do Not Resuscitate (DNR), no escalation of care, or comfort care order at screening
- Expected survival less than 48 hours
- Nasal or oral spillage likely causing bloody secretions
- Requirement for 100% oxygen (FIO2)
- Known allergy to tranexamic acid
- Previous treatment with inhaled tranexamic acid before screening
- Acquired defective color vision
- Subarachnoid hemorrhage
- Deep venous or arterial thrombus diagnosed within past 3 months
- Seizure disorder on active anti-epileptic treatment
- Hypersensitivity to tranexamic acid or its ingredients
- Pregnant women
- Receiving concurrent anti-fibrinolytic therapy
- Confirmed active COVID-19 infection
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
N
Nisha Rathi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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