Actively Recruiting
A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2026-05-14
86
Participants Needed
1
Research Sites
179 weeks
Total Duration
On this page
Sponsors
T
The First Affiliated Hospital with Nanjing Medical University
Lead Sponsor
S
Shanghai Zhongshan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment period of 3 years. An LOT-CRT group will be compared with a group of conventional BiVP in the follow-up of at least 6 months. The study aimed to compare the curative effect of LOT-CRT in preserving LV systolic function with traditional BiVP in chronic heart failure patients with NICD.
CONDITIONS
Official Title
A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ischemic or non ischemic cardiomyopathy
- Optimal medical therapy for at least 3 months
- NYHA class II to IV heart failure
- Left ventricular ejection fraction of 35% or less as measured by echocardiography
- Sinus rhythm (may include paroxysmal atrial fibrillation)
- QRS duration of 150 milliseconds or more
- Nonspecific intraventricular conduction delay (QRS morphology is neither left bundle branch block nor right bundle branch block)
You will not qualify if you...
- Valvular heart disease requiring or having undergone surgery
- Mechanical tricuspid valve replacement
- Persistent or permanent atrial fibrillation or atrial flutter
- Second or third degree atrioventricular block
- Acute myocardial infarction within 3 months before enrollment
- Expected survival time less than 12 months
- Pregnancy or planning to conceive
- Ventricular septal hypertrophy with thickness over 15 mm at end of diastole
- Simple and persistent left superior vena cava
- Existing pacemaker implantation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China, 210029
Actively Recruiting
Research Team
J
Jiangang Zou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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