Comparing Left Bundle Branch Optimized Cardiac Resynchronization Therapy to Standard Biventricular Pacing in Adults with Heart Failure and Nonspecific Intraventricular Conduction Delay

What this Trial Is About

Researchers are studying chronic heart failure patients who have a specific heart conduction problem called nonspecific intraventricular conduction delay NICD. This randomized, controlled trial aims to compare the effects of a newer pacing method called left bundle branch area pacing combined with left ventricular pacing LOT-CRT against the traditional biventricular pacing BiVP method. The goal is to see which method better preserves heart function in patients with NICD over a follow-up period of at least six months. Participants will be randomly assigned to one of two groups. In the LOT-CRT group, patients receive a right atrial lead, an implantable cardioverter defibrillator lead, a left ventricular pacing lead, and a left bundle branch area pacing lead. The BiVP group receives the same leads except for the left bundle branch area pacing lead. The study will follow participants for a minimum of six months to compare the effects of these pacing methods on heart function and clinical outcomes. During the study, participants will undergo assessments including echocardiograms to measure left ventricular ejection fraction at baseline and six months. Other evaluations include paced QRS durations, heart function classifications, quality of life questionnaires, walking tests, blood tests for heart failure biomarkers, and monitoring of arrhythmias and hospitalizations. Researchers will also track the success rate of the left bundle branch area pacing implantation. Safety and clinical outcomes will be closely monitored throughout the study, which is expected to last over three years for recruitment and follow-up.

A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD