Actively Recruiting
A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis
Led by University of California, San Diego · Updated on 2026-04-28
120
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a dietary intervention in women with endometriosis to see if it improves pain and quality of life. This randomized, controlled study compares the effects of a whole food plant-based diet against continuing a usual diet over 12 weeks. The study aims to understand how diet may affect symptoms in women diagnosed with endometriosis. Participants are randomly assigned to either follow the whole food plant-based diet or remain on their usual diet for the 12-week period. The study includes two groups: one receiving the dietary intervention and the other serving as a control group continuing their normal eating habits. The intervention is monitored throughout the study duration to assess its impact. During the study, participants will attend visits and follow procedures to track their health and adherence to the assigned diet. Researchers will measure total pain scores after 12 weeks as the primary outcome. Participants will also be monitored for safety and compliance during the study period, which lasts approximately three months.
CONDITIONS
Brief Title
A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provision of signed and dated informed consent form
- Willingness to comply with all study visits, procedures, requirements, and availability for the duration of the study
- Women with a surgical, imaging, or clinical diagnosis of endometriosis
- Age 18-45 years
- Stable health condition and medications for the past 3 months
- Modified Biberoglu and Behrman pelvic pain score of at least 5 out of 9
- Willing to be randomly assigned to either an active or control group
- Agreement to adhere to Lifestyle Considerations throughout the study duration
You will not qualify if you...
- Smoking or drug abuse during the past six months
- Alcohol consumption of more than 2 drinks per day or a history of alcohol abuse or dependency
- Already following a whole food plant-based diet
- Pregnant or breastfeeding, or planning pregnancy within the study period
- History of hysterectomy or ovariectomy
- Presence of fibroids, ovarian cysts, or pelvic inflammatory disease
- Having endocrine inflammatory conditions such as Cushing's syndrome, Hashimoto's thyroiditis, Graves' disease, type 1 diabetes mellitus, or Addison's disease
- Evidence of an eating disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants follow either a whole food plant-based diet or continue their usual diet to assess improvements in pain and quality of life related to endometriosis.
Weekly visits for 12 weeks
Trial Site Locations
Total: 1 location
1
UCSD Health
La Jolla, California, United States, 92093
Actively Recruiting
Research Team
C
Chloe Delgado Ramirez
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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