Actively Recruiting
A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks
Led by Asian Institute of Gastroenterology, India · Updated on 2026-03-06
414
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary Objective • To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks among patients treated with Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg once daily. Secondary Objectives * To assess the improvement in reflux symptoms using the GERD-Q score at 8 weeks. * To evaluate the incidence of adverse events across treatment groups.
CONDITIONS
Official Title
A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 to 75 years of age
- Endoscopically confirmed LA grade B, C, or D reflux esophagitis
- GERD symptoms such as heartburn or regurgitation for at least 4 weeks before enrollment
- Willing to provide informed consent and follow study procedures
You will not qualify if you...
- Use of Vonaprazan or Esomeprazole in the last 4 weeks
- Previous esophageal surgery or radiation therapy
- Presence of Barrett's esophagus, esophageal stricture, or cancer
- Pregnant or breastfeeding women
- History of PPI-refractory GERD or severe gastroparesis
- Significant liver or kidney problems (ALT/AST greater than 3 times the upper limit of normal, eGFR less than 30 mL/min)
- Use of NSAIDs, steroids, or blood thinners that affect healing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Asian Institute of Gastroenterology /Aig Hospitals
Hyderabad, Telangana, India, 500082
Actively Recruiting
Research Team
R
Rajesh Goud Mr Maragoni, M.Pharm
CONTACT
Z
Zaheer Dr Nabi, MD DNB
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
3
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