Actively Recruiting
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
Led by The Cleveland Clinic · Updated on 2025-11-20
194
Participants Needed
2
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps. Participants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.
CONDITIONS
Official Title
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (age 18 years or older)
- Polyp size of at least 20 mm
- Flat or superficially raised polyp morphology (Paris classification 1s, 0-IIa, or 0-IIb, or combination)
You will not qualify if you...
- Polyps with previous failed resection attempts or polyp recurrence
- Suspected deep submucosal invasion based on endoscopic or histological assessment
- Polyps with nodules too large (>1-1.5 cm) for cold snare use
- Inflammatory bowel disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Cleveland Clinic Weston
Weston, Florida, United States, 33331
Actively Recruiting
2
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
A
Akram Ahmad, M.D.
CONTACT
M
Michael Nicolas, B.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here