Actively Recruiting
Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance
Led by Sorlandet Hospital HF · Updated on 2026-01-15
4000
Participants Needed
1
Research Sites
1251 weeks
Total Duration
On this page
Sponsors
S
Sorlandet Hospital HF
Lead Sponsor
S
Sykehuset Ostfold
Collaborating Sponsor
AI-Summary
What this Trial Is About
From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.
CONDITIONS
Official Title
Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- High-quality baseline colonoscopy with adequate cleansing and cecal intubation
- Removal of at least one advanced adenoma
- Clean colon with all polyps removed
- Signed informed consent
You will not qualify if you...
- Colorectal cancer
- History of surgical colon resection for any reason
- Genetic cancer syndrome such as adenomatous or serrated polyposis syndrome, Lynch or Lynch-like syndrome
- Ten or more adenomas at baseline colonoscopy (cumulative)
- History of advanced serrated lesion (sessile serrated lesion ≥10mm or with dysplasia)
- Inflammatory bowel disease
- Receiving ongoing palliative care for any reason
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Sørlandet sykehus HF
Arendal, Agder, Norway, 4838
Actively Recruiting
Research Team
Ø
Øyvind Holme
CONTACT
M
Michael Bretthauer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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