Actively Recruiting
Simple Imaging Versus Standard Imaging Selection in Stroke Patients for Endovascular Treatment: the NO-SELECT Randomized Trial
Led by Xinqiao Hospital of Chongqing · Updated on 2025-12-26
1846
Participants Needed
8
Research Sites
17 weeks
Total Duration
On this page
Sponsors
X
Xinqiao Hospital of Chongqing
Lead Sponsor
T
The First Affiliated Hospital of Hainan Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the use of simple imaging methods compared to standard imaging to select stroke patients with anterior large vessel occlusion for thrombectomy treatment. The goal is to see if using simpler imaging techniques like NCCT and CTA is as effective as using more advanced imaging strategies that include CTP and MRI. This trial tests the hypothesis that simple imaging is not worse than the standard approach when it comes to achieving favorable outcomes after treatment. Participants will be randomly assigned to one of two groups: one group will be screened using simple imaging methods (NCCT and CTA), while the other group will be screened using standard imaging methods that include NCCT-ASPECTS, CTA, and CTP. Both groups will undergo endovascular treatment based on the imaging selection. The study compares these two imaging strategies to determine their impact on treatment decisions and patient outcomes. During the study, researchers will evaluate patients' recovery by assessing favorable outcomes at 90 days after endovascular treatment. They will also monitor for safety concerns such as symptomatic intracranial hemorrhage within 48 hours and mortality at 90 days. Participants must be followed for at least 90 days post-treatment to gather these data. The study aims to provide clear information about the best imaging approach for selecting patients for thrombectomy.
CONDITIONS
Brief Title
A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Last known well to hospital arrival time is within 24 hours
- Acute stroke confirmed by clinical symptoms or imaging
- Field Assessment Stroke Triage for Emergency Destination (FAST ED) score of 4 or higher
- Written informed consent obtained from patient or legal representative
You will not qualify if you...
- Allergy to radiographic contrast agents or nitinol devices
- Currently pregnant or lactating (women only)
- Arterial tortuosity or other arterial disease preventing device access to target vessel
- Preexisting neurological or psychiatric disease affecting neurological evaluation
- Multiple vessel occlusions (e.g., bilateral anterior circulation or both anterior and posterior circulation)
- Brain tumors with mass effect (except meningiomas) visible on imaging
- Intracranial aneurysm or arteriovenous malformation
- Terminal illness with life expectancy under 6 months
- Unlikely to be available for 90-day follow-up
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 24 hours from last known well to hospital arrival and treatment
Participants receive endovascular treatment for stroke based on either a simplified or standard imaging selection strategy.
1 treatment visit (in-person)
Duration - 90 days
Participants are monitored for outcomes including neurological recovery and safety up to 90 days after treatment.
Approximately 2 visits within 90 days post-treatment
Trial Site Locations
Total: 8 locations
1
Yijishan Hospital of Wannan Medical College
Wuhu, Anhui, China, 241000
Actively Recruiting
2
Xinqiao Hospital of Army Medical University
Chongqing, Chongqing Municipality, China, 400037
Not Yet Recruiting
3
Wuyi Traditional Chinese Medicine Hospital
Jiangmen, Guangdong, China, 529000
Not Yet Recruiting
4
The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China, 570000
Actively Recruiting
5
Huai'an First People's Hospital
Huai'an, Jiangsu, China, 223001
Actively Recruiting
6
The 904th Hospital of CPLA
Wuxi, Jiangsu, China, 214000
Not Yet Recruiting
7
Jingdezhen First People's Hospital
Jingdezhen, Jiangxi, China, 333000
Actively Recruiting
8
Dalian Central Hospital
Dalian, Liaoning, China, 116000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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