Comparing Simple and Standard Imaging Methods for Selecting Stroke Patients for Endovascular Treatment in the NO-SELECT Trial

What this Trial Is About

Researchers are investigating the use of simple imaging methods compared to standard imaging to select stroke patients with anterior large vessel occlusion for thrombectomy treatment. The goal is to see if using simpler imaging techniques like NCCT and CTA is as effective as using more advanced imaging strategies that include CTP and MRI. This trial tests the hypothesis that simple imaging is not worse than the standard approach when it comes to achieving favorable outcomes after treatment. Participants will be randomly assigned to one of two groups one group will be screened using simple imaging methods NCCT and CTA, while the other group will be screened using standard imaging methods that include NCCT-ASPECTS, CTA, and CTP. Both groups will undergo endovascular treatment based on the imaging selection. The study compares these two imaging strategies to determine their impact on treatment decisions and patient outcomes. During the study, researchers will evaluate patients recovery by assessing favorable outcomes at 90 days after endovascular treatment. They will also monitor for safety concerns such as symptomatic intracranial hemorrhage within 48 hours and mortality at 90 days. Participants must be followed for at least 90 days post-treatment to gather these data. The study aims to provide clear information about the best imaging approach for selecting patients for thrombectomy.

A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)