Actively Recruiting
A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
Led by Xinqiao Hospital of Chongqing · Updated on 2025-12-26
1846
Participants Needed
8
Research Sites
150 weeks
Total Duration
On this page
Sponsors
X
Xinqiao Hospital of Chongqing
Lead Sponsor
T
The First Affiliated Hospital of Hainan Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy. The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.
CONDITIONS
Official Title
A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Last known well to hospital arrival within 24 hours
- Acute stroke confirmed by symptoms or imaging
- FAST ED score of 4 or higher
- Written informed consent from patient or legal representative
You will not qualify if you...
- Allergy to radiographic contrast agents or nitinol devices
- Currently pregnant or lactating (women patients)
- Arterial tortuosity or disease preventing device reach
- Preexisting neurological or psychiatric disease affecting evaluations
- Multiple vessel occlusion (e.g., bilateral anterior circulation or both anterior and posterior circulation)
- Brain tumors with mass effect (except meningiomas)
- Intracranial aneurysm or arteriovenous malformation
- Terminal illness with life expectancy less than 6 months
- Unlikely to be available for 90-day follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Yijishan Hospital of Wannan Medical College
Wuhu, Anhui, China, 241000
Actively Recruiting
2
Xinqiao Hospital of Army Medical University
Chongqing, Chongqing Municipality, China, 400037
Not Yet Recruiting
3
Wuyi Traditional Chinese Medicine Hospital
Jiangmen, Guangdong, China, 529000
Not Yet Recruiting
4
The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China, 570000
Actively Recruiting
5
Huai'an First People's Hospital
Huai'an, Jiangsu, China, 223001
Actively Recruiting
6
The 904th Hospital of CPLA
Wuxi, Jiangsu, China, 214000
Not Yet Recruiting
7
Jingdezhen First People's Hospital
Jingdezhen, Jiangxi, China, 333000
Actively Recruiting
8
Dalian Central Hospital
Dalian, Liaoning, China, 116000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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