Actively Recruiting
RANK-ligand Inhibition to Combat Sarcopenia with Underlying Osteoporosis
Led by Prince of Wales Hospital, Shatin, Hong Kong · Updated on 2024-10-16
120
Participants Needed
1
Research Sites
181 weeks
Total Duration
On this page
Sponsors
P
Prince of Wales Hospital, Shatin, Hong Kong
Lead Sponsor
C
Chinese University of Hong Kong
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study was to conduct a randomized, double-blind, double-dummy active controlled trial to determine the efficacy of denosumab in treating sarcopenia with underlying osteoporosis.
CONDITIONS
Official Title
RANK-ligand Inhibition to Combat Sarcopenia with Underlying Osteoporosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elderly males or females aged 65 years or older
- Diagnosed with osteosarcopenia based on AWGS 2019 guidelines: low appendicular skeletal muscle mass by DXA (men <7.0kg/m2, women <5.4kg/m2) and low handgrip strength (men <28kg, women <18kg) or low physical performance (6-metre walk <1.0m/s or 5-time chair stand test ≥12 seconds)
- Diagnosed with osteoporosis based on WHO criteria with DXA scan T-score ≤ -2.5
- Willing and able to comply with study protocol including follow-up evaluations
You will not qualify if you...
- History of fracture within the last 3 months
- History of prior anti-osteoporotic drug use
- Disease or medication affecting bone or muscle metabolism
- Chairbound or bedbound status
- Unable to provide consent
- Contraindication to Denosumab or Zoledronic Acid
- Underlying malignancy or disease known to cause cachexia
- Severe renal impairment (Creatinine Clearance < 35 ml/min)
- Moderate to severe liver failure (Child-Pugh Class B or C)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Chinese University of Hong Kong
Hong Kong, China
Actively Recruiting
Research Team
R
Ronald Man Yeung Wong
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here