Actively Recruiting
Rapid, Accurate, Cost-effective Assessment of Blood Biomarkers for Diagnosis of Concussion
Led by University of Calgary · Updated on 2026-02-05
225
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
U
University of Calgary
Lead Sponsor
F
Foothills Medical Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to test if a biosensor can accurately measure a blood biomarker in adult patients presenting to the emergency department with concussion. The main questions it aims to answer are: * Does the biosensor measure the blood biomarker of interest with the same accuracy as the current gold-standard assay technique? * Do relationships exist between blood biomarker measurements from the biosensor and any psychological or physical symptoms of concussion? Participants will be asked to provide blood samples at initial visit and 2-, 6-, and 12-weeks after injury while completing questionnaires at each visit, along with a brief (2 min) daily symptom inventory. Researchers will compare the concussion group to a muscle/skeletal injury group to see if measurements from the biosensor are exclusive to concussion.
CONDITIONS
Official Title
Rapid, Accurate, Cost-effective Assessment of Blood Biomarkers for Diagnosis of Concussion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with an uncomplicated concussion according to ICD-10 criteria without intracranial abnormalities
- Aged between 18 and 65 years
- Diagnosed with any form of musculoskeletal injury without comorbidities (for MSK group)
- Aged between 18 and 65 years (for MSK group)
You will not qualify if you...
- Complicated mild traumatic brain injury with positive neuroimaging findings
- Current or history of moderate or severe traumatic brain injury
- History of neurological issues such as stroke, seizures, dementia, or Alzheimer's disease
- History of metabolic diseases including diabetes, liver, kidney, or cardiovascular disease
- Initial visit more than 7 days after injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Foothills Medical Centre
Calgary, Alberta, Canada, T2N 2T9
Actively Recruiting
Research Team
C
Chantel T Debert, MD, MSc
CONTACT
L
Linden C Penner, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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