Actively Recruiting
Rapid Evacuation and Access of Cerebral Hemorrhage Trial
Led by Emory University · Updated on 2026-03-19
600
Participants Needed
21
Research Sites
248 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
T
The Marcus Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care. The standard treatment involves admission to the Intensive Care Unit (ICU) with close monitoring and blood pressure control. It also includes other medical (non-surgical) treatments to prevent more bleeding or another stroke. Sometimes, doctors will recommend surgery to remove the blood if medical treatment alone is not successful. There is evidence that doing minimally invasive surgery early-using a small opening in the skull to remove blood-may help some patients. Researchers aim to understand whether this surgery is better than current medical treatment, which may include surgeries to relieve pressure on the brain in some cases. This study, called REACH, is comparing usual medical care to early minimally invasive surgery so doctors can know which is better for patients.
CONDITIONS
Official Title
Rapid Evacuation and Access of Cerebral Hemorrhage Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-70 years
- Head CT before randomization showing an acute, spontaneous primary intracerebral hemorrhage in the anterior basal ganglia
- Hemorrhage volume between 20 and 80 mL measured by approved methods
- Able to start study treatment within 24 hours after stroke symptom onset or last known well time
- Glasgow Coma Score between 5 and 14
- Historical Modified Rankin Score of 0 or 1
You will not qualify if you...
- Ruptured aneurysm, arteriovenous malformation, vascular anomaly, Moyamoya disease, venous sinus thrombosis, mass or tumor, hemorrhagic conversion of ischemic stroke, or recent intracerebral hemorrhage recurrence
- NIH Stroke Scale score of 5 or less
- Bilateral fixed dilated pupils
- Extensor motor posturing
- Intraventricular hemorrhage involving more than 50% of either lateral ventricle
- Primary thalamic hemorrhage or basal ganglia hemorrhage involving more than 25% of the thalamus
- Infratentorial hemorrhage including midbrain, pons, or cerebellum
- Use of anticoagulants that cannot be quickly reversed
- Active bleeding in other body sites such as retroperitoneal, gastrointestinal, genitourinary, or respiratory tracts
- Uncorrected clotting disorders or low platelet count below 75,000, or INR over 1.4 after correction
- Need for long-term anticoagulation within 5 days of initial hemorrhage
- End-stage kidney or liver disease
- Mechanical heart valve
- History of drug or alcohol dependence interfering with study participation
- Positive pregnancy test without sterilization or menopause
- Life expectancy less than 6 months before hemorrhage
- No expectation of recovery or comfort care only before randomization
- Participation in other interventional medical trials
- Inability or unwillingness to give informed consent
- Homelessness or inability to complete follow-up requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 21 locations
1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
Not Yet Recruiting
2
Stanford University Medical Center
Palo Alto, California, United States, 94304
Not Yet Recruiting
3
Baptist Health Jacksonville FL
Jacksonville, Florida, United States, 32207
Actively Recruiting
4
Baptist Health South Florida
Kendall, Florida, United States, 33176
Not Yet Recruiting
5
Jackson Memorial Hospital (JMH)
Miami, Florida, United States, 33125
Not Yet Recruiting
6
Grady Memorial Hospital
Atlanta, Georgia, United States, 30303
Actively Recruiting
7
Emory Hospital Midtown
Atlanta, Georgia, United States, 30308
Actively Recruiting
8
Emory University Hospital (EUH)
Atlanta, Georgia, United States, 30322
Actively Recruiting
9
Rush University
Chicago, Illinois, United States, 60612
Not Yet Recruiting
10
Endeavor Health, Northshore
Evanston, Illinois, United States, 60201
Actively Recruiting
11
Goodman Campbell Brain and Spine
Carmel, Indiana, United States, 46032
Not Yet Recruiting
12
University of Kentucky
Lexington, Kentucky, United States, 40536
Not Yet Recruiting
13
Johns Hopkins School of Medicine
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
14
University of Missouri
Columbia, Missouri, United States, 65212
Not Yet Recruiting
15
Albany Medical Center
Albany, New York, United States, 12208
Actively Recruiting
16
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
17
Montefiore Medical Center/Albert Einstein School of Medicine
The Bronx, New York, United States, 10467
Not Yet Recruiting
18
The Ohio State University
Columbus, Ohio, United States, 43210
Not Yet Recruiting
19
ProMedica Toledo Hospital
Toledo, Ohio, United States, 43606
Actively Recruiting
20
Rhode Island Hospital/Brown University Health
Providence, Rhode Island, United States, 02912
Actively Recruiting
21
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Not Yet Recruiting
Research Team
A
Alex Hall, DHSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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