Actively Recruiting
Rapid Molecular Diagnosis of Sepsis in the Intensive Care Unit
Led by Maastricht University Medical Center · Updated on 2024-10-03
300
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
M
Maastricht University Medical Center
Lead Sponsor
H
Health Holland
Collaborating Sponsor
AI-Summary
What this Trial Is About
Rapid diagnosis of sepsis is crucial for treatment and survival. Currently, blood culture takes 48 hours-5 days to complete. After starting antimicrobial treatment blood culture results are not reliable. As a result, empirical broad spectrum antimicrobial therapy is mostly used. This implies possible antimicrobial over- or under treatment which is associated with increased antimicrobial resistance development. Early identification of the causative pathogen of sepsis will therefore have a major impact on the adequate treatment and reduction of high mortality rates. To date, there is not a single molecular diagnostic test available on the market to detect all putative causative bacterial pathogens of sepsis. In this study, the investigators will develop and validate a completely new molecular sepsis approach based on pathogen DNA detection, as an alternative to culture.
CONDITIONS
Official Title
Rapid Molecular Diagnosis of Sepsis in the Intensive Care Unit
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients are included when routine blood cultures are ordered for diagnosis of bloodstream infections.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Maastricht University Medical Center
Maastricht, Limburg, Netherlands, 6229 HX
Actively Recruiting
Research Team
A
Anna Wijen, Msc.
CONTACT
P
Paul Savelkoul, Prof. Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here