Actively Recruiting
Prehospital Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study in Prague
Led by General University Hospital, Prague · Updated on 2025-02-14
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the feasibility and effectiveness of starting extracorporeal cardiopulmonary resuscitation (ECPR) before reaching the hospital in patients who have a refractory out-of-hospital cardiac arrest (OHCA). This pilot prospective study compares this prehospital ECPR approach in Prague with historical data from patients who received ECPR within the hospital setting during the Prague OHCA trial. The study involves delivering prehospital ECPR to all enrolled patients meeting the criteria. This intervention is compared to a historical control group of patients who received in-hospital ECPR and met similar inclusion and exclusion criteria. The study tracks the time from estimated collapse to the start of ECPR, aiming to assess the timing and feasibility of this prehospital method. Participants will experience rapid response with an ECPR team alerted within 20 minutes of the emergency call. Outcome measures include the time from collapse to ECPR initiation, survival rates at 30 days, and neurological function assessed by the Modified Rankin Scale at 30 days. The study will monitor participants closely during this period to evaluate the impact of prehospital ECPR on outcomes compared to the historical group.
CONDITIONS
Brief Title
Rapid Prehospital ACcess to ECPR in Prague
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Estimated age between 18 and 70 years
- Refractory out-of-hospital cardiac arrest with 3 unsuccessful defibrillations or at least 10 minutes of resuscitation for pulseless electrical activity
- Witnessed cardiac arrest
- Availability of the ECPR team
- ECPR team alert within 20 minutes from the emergency call
You will not qualify if you...
- Unwitnessed cardiac arrest
- Asystole
- End-tidal CO2 less than 10 mmHg upon ECPR team arrival
- Known limitations of intensive care such as Do Not Resuscitate (DNR) status
- Known severe neurological impairment prior to cardiac arrest (Modified Rankin Scale 4-6)
- Suspected or known pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
screening and enrollment visit
Duration - Duration from estimated collapse to start of ECPR ranges from 20 to 100 minutes
Participants receive prehospital extracorporeal cardiopulmonary resuscitation (ECPR) after refractory out-of-hospital cardiac arrest.
1 prehospital treatment visit
Duration - 30 days
Participants are monitored for survival and neurological function up to 30 days after treatment.
1 visit at 30 days post-treatment
Trial Site Locations
Total: 1 location
1
General University Hospital in Prague
Prague, Czechia, Czechia, 12800
Actively Recruiting
Research Team
J
Jan Belohlavek, MD, PhD
D
Daniel Rob, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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