Pilot Study of Rapid Prehospital Extracorporeal Cardiopulmonary Resuscitation ECPR for Out-of-Hospital Cardiac Arrest in Prague

What this Trial Is About

Researchers are evaluating the feasibility and effectiveness of starting extracorporeal cardiopulmonary resuscitation ECPR before reaching the hospital in patients who have a refractory out-of-hospital cardiac arrest OHCA. This pilot prospective study compares this prehospital ECPR approach in Prague with historical data from patients who received ECPR within the hospital setting during the Prague OHCA trial. The study involves delivering prehospital ECPR to all enrolled patients meeting the criteria. This intervention is compared to a historical control group of patients who received in-hospital ECPR and met similar inclusion and exclusion criteria. The study tracks the time from estimated collapse to the start of ECPR, aiming to assess the timing and feasibility of this prehospital method. Participants will experience rapid response with an ECPR team alerted within 20 minutes of the emergency call. Outcome measures include the time from collapse to ECPR initiation, survival rates at 30 days, and neurological function assessed by the Modified Rankin Scale at 30 days. The study will monitor participants closely during this period to evaluate the impact of prehospital ECPR on outcomes compared to the historical group.

Rapid Prehospital ACcess to ECPR in Prague