Actively Recruiting
Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)
Led by University of California, San Francisco · Updated on 2026-03-11
2100
Participants Needed
3
Research Sites
135 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
I
Instituto Nacional de Saúde, Mozambique
Collaborating Sponsor
AI-Summary
What this Trial Is About
Every year there are an estimated 230,000 childhood deaths from TB. There is an urgent need for novel tests for TB diagnosis in children under 15 years. The Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and the Assessing Diagnostics at Point-of-care for Tuberculosis in children (ADAPT for Kids) studies seek to reduce the burden of TB worldwide by evaluating faster, simpler, and less expensive TB triage and diagnostic tests for use in children.
CONDITIONS
Official Title
Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children younger than 15 years who present to care with either:
- At least two of the following: unexplained cough of any duration, TB contact or positive TB skin or blood test, or any abnormal chest X-ray
- Or one of the above plus one of the following: unexplained weight loss, failure to thrive, severe acute malnutrition, unexplained fever for 2 or more weeks, or unexplained lethargy or reduced playfulness for 2 or more weeks
- Health workers aged 18 years or older involved in routine TB testing who provide consent
You will not qualify if you...
- Completed preventive or active TB treatment within the past 12 months
- Taken anti-mycobacterial medication for more than 3 days at enrollment
- Unable to return for follow-up visits
- Parents/guardians unwilling to provide informed consent or assent
- Health workers unwilling to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Instituto Nacional de Saúde
Maputo, Mozambique
Actively Recruiting
2
Dora Nginza Hospital
Cape Town, South Africa
Not Yet Recruiting
3
Mulago National Referral Hospital
Kampala, Uganda
Not Yet Recruiting
Research Team
D
Devan Jaganath, MD
CONTACT
B
Brittney Sweetser, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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