Actively Recruiting
RAPid SimPLE Targeted Radiation Treatment for Brain Metastases
Led by British Columbia Cancer Agency · Updated on 2025-04-17
100
Participants Needed
6
Research Sites
286 weeks
Total Duration
On this page
Sponsors
B
British Columbia Cancer Agency
Lead Sponsor
V
Varian Medical Systems
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the study is to show that rapid, simple targeted radiotherapy to brain metastases with 8 Gy / 1 is non-inferior to 20 Gy / 5 in terms of overall survival for patients with poor prognosis.
CONDITIONS
Official Title
RAPid SimPLE Targeted Radiation Treatment for Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Pathological diagnosis of a non-hematopoietic malignancy
- Brain metastases of any size
- Any number of untreated or progressing, previously treated brain metastases that can all be contoured and targeted
- Presence of extracranial disease
- Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) score 2.0 or less
- Able to complete the EuroQOL (EQ-5D-5L) questionnaire
- Willing and able to have regular imaging follow-up
- Feasible to start protocol treatment within 14 days of enrollment
- Karnofsky Performance Score (KPS) 50 or higher
You will not qualify if you...
- Inability to have a brain MRI
- Whole brain radiotherapy (WBRT) less than 3 months before randomization
- Disseminated leptomeningeal carcinomatosis (limited pachymeningeal disease allowed)
- Multiple sclerosis
- Neurologically declining despite corticosteroids
- Appropriate for surgery or stereotactic radiosurgery
- Germ cell and primary brain tumors
- Systemic lupus erythematosus, scleroderma, or other connective tissue disorders not in remission
- Any serious illness or medical condition compromising safety or protocol compliance
- Pregnancy
- Potentially fertile men or women of childbearing potential unwilling to use effective contraception
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
BC Cancer - Abbotsford
Abbotsford British Columbia, British Columbia, Canada
Actively Recruiting
2
BC Cancer - Kelowna
Kelowna, British Columbia, Canada, V1Y5L3
Actively Recruiting
3
BC Cancer - Prince George
Prince George, British Columbia, Canada, V2M7E9
Actively Recruiting
4
BC Cancer - Surrey
Surrey, British Columbia, Canada
Actively Recruiting
5
BC Cancer - Vancouver
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
6
BC Cancer - Victoria
Victoria, British Columbia, Canada
Actively Recruiting
Research Team
S
Sandy Chang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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