Actively Recruiting
A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)
Led by Barcelona Institute for Global Health · Updated on 2026-02-17
5212
Participants Needed
2
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall aim of the study is to provide evidence that introducing novel biomarkers evaluation at triaging (first clinical assessment), in combination with IMCI-based guidelines (SoC), is a viable strategy to enhance rapid and accurate identification of febrile children at increased risk of life-threatening infections compared to IMCI-based strategies alone (SoC), and to demonstrate whether this results in enhanced decisions of admission/referral vs discharge, and enhanced overall health outcome of children with acute fever in sub-Saharan Africa.
CONDITIONS
Official Title
A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 2 months or older and under 60 months
- Written informed consent from the child's parent or caregiver
- History of fever for 7 days or less OR low axillary temperature below 35.5°C OR suspected severe infection
- Lives within the study facility's catchment area and plans to remain there for the study duration
- For respiratory tract infection sub-study: presence of respiratory symptoms compatible with RTI
You will not qualify if you...
- Weight less than 2.5 kilograms
- Main reason for consultation is injury, trauma, or acute poisoning
- Currently enrolled in another clinical trial testing a new drug
- Enrolled in a vaccine trial within the last 3 months
- Any condition making it unlikely the participant will complete the study as determined by investigators
AI-Screening
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Trial Site Locations
Total: 2 locations
1
CERMEL Centre de Recherches Médicales de Lambaréné
Lambaréné, Moyen-Ogooué Province, Gabon, 242
Actively Recruiting
2
Mopeia Sede Health Centre
Mopeia, Mozambique
Actively Recruiting
Research Team
Q
Quique Bassat, Prof
CONTACT
B
Barbara Baro, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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