Rare and Atypical Diabetes Network Study to Identify and Understand New Forms of Diabetes Using Genetic and Clinical Testing

What this Trial Is About

Researchers are investigating rare and atypical forms of diabetes to better understand their unique causes and mechanisms. This study, conducted through the RADIANT network of 14 clinical sites and laboratories, aims to identify individuals and families with undiagnosed rare diabetes types, determine the underlying causes, and explore the diseases effects on the body. The study has three stages. In Stage 1, participants complete a consent form and questionnaire to identify possible atypical diabetes, followed by blood tests for autoantibodies and further questionnaires. Selected participants move to Stage 2, which involves genetic screening, family history assessments, and whole genome sequencing of DNA samples. Stage 3 includes in-depth testing such as an Oral Glucose Tolerance Test, more blood collection, physical exams, and detailed questionnaires. The Discovery Team reviews all data to understand novel genetic variants and may enroll family members for similar testing or recommend additional procedures. Participants provide samples, complete questionnaires, and attend clinic visits for physical exams and glucose tolerance testing. Researchers collect and analyze genetic and metabolic data to characterize new diabetes types. The main outcome is phenotypic and genetic characterization over about three years. Family members may also participate if needed. The study is observational, with no treatment given, and aims to improve understanding of atypical diabetes.

Rare and Atypical Diabetes Network