Actively Recruiting
Rare and Atypical Diabetes Network
Led by University of South Florida · Updated on 2025-08-14
2000
Participants Needed
13
Research Sites
517 weeks
Total Duration
On this page
Sponsors
U
University of South Florida
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. 2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical diabetes. 3. Understand the pathophysiology of individuals and families with novel forms of rare and atypical forms of diabetes.
CONDITIONS
Official Title
Rare and Atypical Diabetes Network
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diabetes type 2 diagnosed before puberty or in non-obese individuals
- Early onset diabetes less than 18 years old or Mendelian inheritance pattern
- Syndromic diabetes involving multiple systems
- Lipodystrophic features
- Extreme body mass index (BMI) values
- Mitochondrial-related symptoms such as myopathy or hearing deficits
- Non-progressive diabetes
- Rapidly progressive or "fulminant" diabetes
- Low insulin requirements less than 0.5 units/kg/day
- Cyclical hyperglycemia with remission periods
- Lean persons with polycystic ovarian syndrome (PCOS)
- History of gestational diabetes when lean
- Lean individuals with insulin resistance
- Participants with specific islet autoantibody and beta-cell function profiles as described
You will not qualify if you...
- High likelihood of typical type 1 or type 2 diabetes, known monogenic or secondary diabetes
- Refusal to consent for genetic testing
- Positive islet autoantibody test unless accompanied by atypical features or strong family history
- Women who are currently pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
University of Colorado- Denver
Aurora, Colorado, United States, 80045
Actively Recruiting
2
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
3
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
4
University of Maryland
Baltimore, Maryland, United States, 21201
Actively Recruiting
5
Massachusetts General Hospital (MGH)
Boston, Massachusetts, United States, 02114
Actively Recruiting
6
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
7
Washington University in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
8
SUNY Downstate Health Sciences University
Brooklyn, New York, United States, 11203
Actively Recruiting
9
Columbia University
New York, New York, United States, 10032
Actively Recruiting
10
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
11
Vanderbilt University
Nashville, Tennessee, United States, 37232
Actively Recruiting
12
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
13
University of Washington
Seattle, Washington, United States, 98109
Actively Recruiting
Research Team
J
Jeffrey Krischer, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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