Actively Recruiting
Rate or Rhythm Control in CRT: the RHYTHMIC Study
Led by Guy's and St Thomas' NHS Foundation Trust · Updated on 2026-01-26
70
Participants Needed
1
Research Sites
310 weeks
Total Duration
On this page
Sponsors
G
Guy's and St Thomas' NHS Foundation Trust
Lead Sponsor
K
King's College London
Collaborating Sponsor
AI-Summary
What this Trial Is About
70 patients with heart failure, AF and CRT with BiV\<95% will be randomised to either AF ablation or AV node ablation. Evaluation at 6 months with echocardiography and clinical assessment.
CONDITIONS
Official Title
Rate or Rhythm Control in CRT: the RHYTHMIC Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent and willing to follow the study plan and follow-up
- QRS duration greater than 120ms on ECG, left ventricular ejection fraction of 35% or less, and heart failure symptoms (NYHA class II-IV) at time of CRT implant or upgrade
- Successful CRT implant or upgrade including an atrial lead
- Biventricular pacing less than 95% due to atrial fibrillation at least 3 months after CRT implant or upgrade
- Clinically indicated for AV node ablation
You will not qualify if you...
- Life expectancy less than 1 year
- Presence of atrial or ventricular blood clot
- Permanent atrial fibrillation
- Mechanical aortic valve replacement
- Severe peripheral vascular disease
- Female participants who are pregnant, breastfeeding, or planning pregnancy during the study
- Participation in other studies involving active treatment or investigational therapies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Guys and St Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH
Actively Recruiting
Research Team
C
Christopher A Rinaldi
CONTACT
F
Felicity de Vere
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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