Study of Combined Vibration Treatment and HMB Supplement to Slow Muscle Loss and Improve Strength in Older Adults with Sarcopenia

What this Trial Is About

Researchers are evaluating the combined effect of vibration treatment VT and -hydroxy -methylbutyrate HMB supplementation on sarcopenia, a condition characterized by muscle loss and weakness in older adults. A previous animal study showed that this combination reduced fat infiltration, increased lean muscle mass, and improved muscle strength. This study aims to confirm these benefits in people aged 60 and above who show signs of sarcopenia, with the goal to slow its progression by improving muscle mass, strength, and performance. Participants will be randomly assigned to one of four groups control protein supplement only, HMB supplement only, VT only, or both HMB and VT together. VT involves using a device delivering low-magnitude, high-frequency vibrations 0.3g, 35Hz for 20 minutes per day at least three times a week, while HMB is taken as a daily 3g oral supplement. All groups receive daily protein supplements for six months. Outcomes will be measured at the start, midpoint, and end of the six-month treatment period. During the study, participants will undergo assessments including handgrip strength, gait speed, muscle mass by DXA, balance tests, and quality of life surveys. These evaluations will occur at baseline, 3 months, and 6 months to monitor changes. The primary focus is on muscle strength and physical performance. The study is single-blinded and conducted by the Chinese University of Hong Kong, with careful monitoring throughout the six-month duration.

RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration