Effects of 18-month low-magnitude high-frequency vibration on fall rate and fracture risks in 710 community elderly--a cluster-randomized controlled trial.
K S Leung, C Y Li, Y K Tse...
https://pubmed.ncbi.nlm.nih.gov/24676848Actively Recruiting
Phase Not Applicable
Age: 60Years +
All Genders
ID05525039
Dissecting the Therapeutic Mechanism of a Combined Vibration Treatment and HMB Supplement to Combat Sarcopenia
Led by Chinese University of Hong Kong · Updated on 2025-02-13
200
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Chinese University of Hong Kong
Lead Sponsor
A
Abbott
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the combined effect of vibration treatment (VT) and -hydroxy -methylbutyrate (HMB) supplementation on sarcopenia, a condition characterized by muscle loss and weakness in older adults. A previous animal study showed that this combination reduced fat infiltration, increased lean muscle mass, and improved muscle strength. This study aims to confirm these benefits in people aged 60 and above who show signs of sarcopenia, with the goal to slow its progression by improving muscle mass, strength, and performance. Participants will be randomly assigned to one of four groups: control (protein supplement only), HMB supplement only, VT only, or both HMB and VT together. VT involves using a device delivering low-magnitude, high-frequency vibrations (0.3g, 35Hz) for 20 minutes per day at least three times a week, while HMB is taken as a daily 3g oral supplement. All groups receive daily protein supplements for six months. Outcomes will be measured at the start, midpoint, and end of the six-month treatment period. During the study, participants will undergo assessments including handgrip strength, gait speed, muscle mass by DXA, balance tests, and quality of life surveys. These evaluations will occur at baseline, 3 months, and 6 months to monitor changes. The primary focus is on muscle strength and physical performance. The study is single-blinded and conducted by the Chinese University of Hong Kong, with careful monitoring throughout the six-month duration.
CONDITIONS
Brief Title
RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration
Who Can Participate
Age: 60Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Subjects aged 60 years or above
- Subjects who have sarcopenia based on AWGS algorithm including low skeletal muscle mass by bioelectrical impedance, low handgrip strength, and/or slow gait speed
You will not qualify if you...
- Subjects with pathological bone diseases
- Subjects with chronic inflammatory conditions such as rheumatoid arthritis
- Subjects with neurological problems affecting gait
- Subjects receiving regular supervised exercise more than 3 times per week
- Subjects who are chair-bound or bed-bound
- Subjects with malignancy
- Subjects with cardiovascular concerns such as having a pacemaker
- Subjects with acute fractures or severe osteoarthritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Participants are screened by SARC-F, handgrip, gait speed, and bioelectric impedance assessments based on the AWGS definition.
Treatment
Duration - 6 months
Participants receive assigned interventions including vibration treatment, HMB supplement, and daily protein supplement according to their group assignment.
Visits at baseline, 3 months, and 6 months post-treatment at the investigators' institute for outcome assessments.
Trial Site Locations
Total: 3 locations
1
Evangelical Luthera Church Social Service - Hong Kong
Hong Kong, Hong Kong
Active, Not Recruiting
2
The Chinese University of Hong Kong Jockey Club Centre for Osteoporosis Care and Control
Hong Kong, Hong Kong
Actively Recruiting
3
The Chinese University of Hong Kong, Department of Orthopaedics and Traumatology, 1/F Li Ka Shing Outpatient Clinic (North), PWH
Hong Kong, Hong Kong
Actively Recruiting
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Research Team
W
Wing Hoi Cheung, PhD
M
Meng Chen Michelle Li, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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Published Research Related To This Trial
Vibration and β-hydroxy-β-methylbutyrate treatment suppresses intramuscular fat infiltration and adipogenic differentiation in sarcopenic mice.
Jinyu Wang, Can Cui, Yu Ning Chim...
https://pubmed.ncbi.nlm.nih.gov/31994349Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults.
Nicolaas E P Deutz, Suzette L Pereira, Nicholas P Hays...
https://pubmed.ncbi.nlm.nih.gov/23514626High-frequency whole-body vibration improves balancing ability in elderly women.
Wing-Hoi Cheung, Hoi-Wa Mok, Ling Qin...
https://pubmed.ncbi.nlm.nih.gov/17601464Effects of exercise and nutrition supplementation in community-dwelling older Chinese people with sarcopenia: a randomized controlled trial.
Liu-Ying Zhu, Ruth Chan, Timothy Kwok...
https://pubmed.ncbi.nlm.nih.gov/30462162Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia.
Liang-Kung Chen, Li-Kuo Liu, Jean Woo...
https://pubmed.ncbi.nlm.nih.gov/24461239Biophysical and nutritional combination treatment for myosteatosis in patients with sarcopenia: a study protocol for single-blinded randomised controlled trial.
Meng Chen Michelle Li, Yu Kin Cheng, Can Cui...
https://pubmed.ncbi.nlm.nih.gov/38176874