Actively Recruiting
RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration
Led by Chinese University of Hong Kong · Updated on 2025-02-13
200
Participants Needed
3
Research Sites
137 weeks
Total Duration
On this page
Sponsors
C
Chinese University of Hong Kong
Lead Sponsor
A
Abbott
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators' pre-clinical study confirms the positive effects of combined treatment (VT + HMB) on reducing fat-to-lean tissue ratio, intramuscular fat infiltration and increasing muscle strength in sarcopenia animal model. The results showed that fat mass could be decreased by \~32%, while histology Oil Red O staining indicated a decrease of fat by almost 60%; in contrast, lean muscle mass increased by \~14%. On muscle strength, combined treatment increased twitch force, tetanic force and grip strength by \~30-66%. These in vivo results are very encouraging and the investigators should explore its potential in clinical translation. As VT and HMB supplement have been commercially available and their compliance rates are satisfactory, they can be translated to clinical application easily. The investigators' next step is to confirm its clinical efficacy, so that sarcopenia becomes a new indication of VT and HMB. The hypothesis is that combined treatment of VT and HMB can retard the progression of sarcopenia in human, in terms of muscle mass, muscle strength and performance.
CONDITIONS
Official Title
RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects aged 60 years or above
- Subjects who fail the AWGS sarcopenia algorithm based on at least one of the following: skeletal muscle mass measured by BIA (male <7.0 kg/m2, female <5.7 kg/m2), handgrip strength (male <28 kg, female <18 kg), or gait speed test (≤1 m/s)
You will not qualify if you...
- Subjects with pathological bone diseases
- Subjects with chronic inflammatory conditions such as rheumatoid arthritis
- Subjects with neurological problems affecting gait
- Subjects receiving regular supervised exercise training more than 3 times per week
- Subjects who are chair-bound or bed-bound
- Subjects with malignancy
- Subjects with cardiovascular concerns such as having a pacemaker
- Subjects with acute fractures or severe osteoarthritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Evangelical Luthera Church Social Service - Hong Kong
Hong Kong, Hong Kong
Active, Not Recruiting
2
The Chinese University of Hong Kong Jockey Club Centre for Osteoporosis Care and Control
Hong Kong, Hong Kong
Actively Recruiting
3
The Chinese University of Hong Kong, Department of Orthopaedics and Traumatology, 1/F Li Ka Shing Outpatient Clinic (North), PWH
Hong Kong, Hong Kong
Actively Recruiting
Research Team
W
Wing Hoi Cheung, PhD
CONTACT
M
Meng Chen Michelle Li, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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