Actively Recruiting
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
Led by University Hospital Southampton NHS Foundation Trust · Updated on 2026-03-05
2504
Participants Needed
47
Research Sites
676 weeks
Total Duration
On this page
Sponsors
U
University Hospital Southampton NHS Foundation Trust
Lead Sponsor
B
British Heart Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
BRITISH is a UK multicentre trial of patients who have been diagnosed with heart failure due to Non-Ischemic Cardiomyopathy (NICM, or heart failure that is not caused by blocked heart arteries. Participants will be randomised into two groups. Half the participants will receive an Implantable Cardioverter-Defibrillator (ICD) and the other half will not. The aim of the study will be to compare all-cause mortality (death from any cause) between these two groups at 36 months, and longer-term to 10 years. The study has the potential to change international heart failure treatment guidelines and to improve how patients with this condition are managed.
CONDITIONS
Official Title
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Non-Ischemic Cardiomyopathy confirmed by contrast-enhanced cardiovascular magnetic resonance imaging
- Presence of left ventricular scar on routine cardiovascular magnetic resonance (patients without scar can enter registry)
- New York Heart Association (NYHA) Heart Failure class I to III with severely reduced left ventricular function (LVEF ≤ 35%) after at least 3 months of optimal medical therapy
- Able and willing to provide informed consent
You will not qualify if you...
- New York Heart Association (NYHA) Heart Failure class IV after 3 months of optimal medical therapy
- Acute decompensated heart failure
- Previous implantable cardiac device such as pacemaker, cardiac resynchronisation therapy device, or ICD
- Ischemic cardiomyopathy with significant wall motion abnormalities and scarring in specific coronary territories
- Known amyloidosis, sarcoidosis, arrhythmogenic right ventricular cardiomyopathy, or hypertrophic cardiomyopathy
- Known Lamin gene mutation or family history of Lamin gene mutation
- Valve disease likely to require surgery within 3 years
- Complex congenital heart disease
- Secondary prevention ICD indication
- Heart transplant recipient or listed for transplantation or ventricular assist device
- Clinically apparent myocardial ischemia requiring revascularization
- Intracardiac mass requiring surgery
- Active endocarditis or septicaemia
- Pregnancy
- Life expectancy less than 2 years due to other causes
- Active chemotherapy treatment
- Severe renal failure (GFR <30)
- Participation in another study without agreement from chief investigators
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 47 locations
1
Wycombe Hospital
High Wycombe, Buckinghamshire, United Kingdom, HP11 2TT
Actively Recruiting
2
Derriford Hospital
Plymouth, Devon, United Kingdom, PL6 8DH
Actively Recruiting
3
Royal Bournemouth Hospital
Bournemouth, Dorset, United Kingdom, BH7 7DW
Actively Recruiting
4
Durham & Darlington NHS Foundation Trust
Darlington, Durham, United Kingdom, DL3 6HX
Actively Recruiting
5
Royal Sussex County Hospital
Brighton, East Sussex, United Kingdom, BN2 5BE
Actively Recruiting
6
Essex Cardiothoracic Centre
Basildon, Essex, United Kingdom, SS16 5NL
Actively Recruiting
7
James Paget University Hospitals NHS FT
Gorleston-on-Sea, Great Yarmouth, United Kingdom, NR31 6LA
Actively Recruiting
8
Portsmouth Hospitals University NHS Trust
Portsmouth, Hampshire, United Kingdom, PO6 3LY
Actively Recruiting
9
Southampton Clinical Trials Unit
Southampton, Hampshire, United Kingdom, SO16 6YD
Not Yet Recruiting
10
University Hospital Southampton NHS Foundation Trust
Southampton, Hampshire, United Kingdom, SO16 6YD
Actively Recruiting
11
Kent & Canterbury Hospital
Canterbury, Kent, United Kingdom, CT1 3NG
Actively Recruiting
12
Maidstone Hospital, Maidstone & Tunbridge Wells NHS Trust
Maidstone, Kent, United Kingdom, ME16 9QQ
Actively Recruiting
13
Blackpool Victoria Hospiatal
Blackpool, Lancashire, United Kingdom, FY3 8NR
Actively Recruiting
14
Liverpool Heart & Chest
Liverpool, Lancashire, United Kingdom, L14 3PE
Actively Recruiting
15
Glenfield Hospital
Leicester, Leicestershire, United Kingdom, LE3 9QP
Actively Recruiting
16
St Bartholomew's Hospital
London, London, United Kingdom, EC1A 7BE
Actively Recruiting
17
Royal Free Hospital
London, London, United Kingdom, NW3 2QG
Actively Recruiting
18
Guy's Hospital
London, London, United Kingdom, SE1 9RT
Actively Recruiting
19
King's College Hospital
London, London, United Kingdom, SE5 9RS
Actively Recruiting
20
Royal Brompton Hospital
London, London, United Kingdom, SW3 6NP
Actively Recruiting
21
Hammersmith Hospital, Imperial College Healthcare NHS Trust
London, London, United Kingdom, Wq12 0HS
Actively Recruiting
22
St George's Hospital
Tooting, London, United Kingdom, SW17 0QT
Actively Recruiting
23
Fairfield General Hospital, Northern Care Alliance NHS FT
Manchester, Manchester, United Kingdom, BL9 7TD
Actively Recruiting
24
Newcastle Freeman Hospital
Newcastle, Newcastle Upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
25
The James Cook University Hospital
Middlesbrough, North Yorkshire, United Kingdom, TS4 3BW
Actively Recruiting
26
Wansbeck General Hospital
Ashington, Northumbria, United Kingdom, NE63 9JJ
Active, Not Recruiting
27
Scarborough Hospital
Scarborough, Nortrh Yorkshire, United Kingdom, YO12 6QL
Actively Recruiting
28
Nottingham City Hospital
Nottingham, Nottinghamshire, United Kingdom, NG5 1PB
Actively Recruiting
29
The John Radcliffe Hospital
Oxford, Oxfordshire, United Kingdom, OX3 9DU
Actively Recruiting
30
Aberdeen Royal Infirmary
Aberdeen, Scotland, United Kingdom, AB25 2ZN
Actively Recruiting
31
Royal Infirmary of Edinburgh
Edinburgh, Scotland, United Kingdom, EH16 4SA
Actively Recruiting
32
Musgrove Park Hospital
Taunton, Somerset, United Kingdom, TA1 5DA
Active, Not Recruiting
33
Northern General Hospital
Sheffield, South Yorkshire, United Kingdom, S5 7AU
Actively Recruiting
34
University Hospital of North Tees
Hardwick, Stockton-on-Tees, United Kingdom, TS19 8PE
Actively Recruiting
35
Frimley Park Hospital
Camberley, Surrey, United Kingdom, GU16 7UJ
Actively Recruiting
36
Surrey & Sussex Healthcare NHS Trust
Redhill, Surrey, United Kingdom, RH1 5RH
Actively Recruiting
37
University Hospital of Wales
Cardiff, Wales, United Kingdom, CF14 4XW
Actively Recruiting
38
University Hospital Coventry
Coventry, Warwickshire, United Kingdom, CV2 2DX
Actively Recruiting
39
New Cross Hospital
Wolverhampton, West Midlands, United Kingdom, WV10 0QP
Actively Recruiting
40
St Richards Hospital
Chichester, West Sussex, United Kingdom, PO19 6SE
Actively Recruiting
41
Leeds General Infirmary
Leeds, West Yorkshire, United Kingdom, LS1 3EX
Actively Recruiting
42
Pinderfields Hospital
Wakefield, West Yorkshire, United Kingdom, WF1 4DG
Actively Recruiting
43
Worcestershire Royal Hospital
Worcester, Worcestershire, United Kingdom, WR5 1DD
Actively Recruiting
44
Wythenshaw Hospital
Manchester, Wythenshaw, United Kingdom, M23 9LT
Actively Recruiting
45
Castle Hill Hospital
Hull, Yorkshire, United Kingdom, HU16 5JQ
Actively Recruiting
46
Royal Devon & Exeter Hospital
Exeter, United Kingdom, EX2 5DW
Actively Recruiting
47
Morriston Hospital
Swansea, United Kingdom, SA6 6NL
Actively Recruiting
Research Team
Z
Zina Eminton
CONTACT
Z
Zoe Nicholas
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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