Actively Recruiting
RCT on Intralesional Rituximab Injection Versus ISRT in Ocular Adnexal MALT Lymphoma
Led by Zhongshan Ophthalmic Center, Sun Yat-sen University · Updated on 2026-04-20
108
Participants Needed
1
Research Sites
314 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project proposes to establish a prospective, multicenter, randomized, controlled clinical study to compare the safety and efficacy of Intralesional Rituximab Injection versus Involved Site Radiation Therapy for the treatment of primary ocular adnexal MALT lymphoma. The aim is to provide high-level clinical evidence for the treatment of ocular adnexal MALT lymphoma and to offer patients treatment options that have fewer complications and comparable therapeutic effects.
CONDITIONS
Official Title
RCT on Intralesional Rituximab Injection Versus ISRT in Ocular Adnexal MALT Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 to 75 years old
- Diagnosed primary ocular adnexal MALT lymphoma based on pathology, clinical signs, and WHO classification
- TNM staging T1-3 without involvement of intraconal compartment
- Willing to participate and able to sign informed consent
You will not qualify if you...
- TNM staging T2/T3 with intraconal compartment involvement or stage T4
- Previous local or systemic radiation, chemotherapy, or drug treatment for ocular adnexal MALT lymphoma
- Presence of cataract requiring surgery soon or cataract affecting vision below 20/40
- Need for other ocular surgeries besides lymphoma treatment
- Other ocular diseases including corneal infections, iridocorneal endothelial syndrome, microphthalmos, uveitis, glaucoma, ocular trauma, retinal disorders
- Presence of HBV or HIV infection
- Requirement for long-term local or systemic steroid use
- Participation in other drug clinical trials
- Pregnant or breastfeeding women
- Serious systemic diseases such as advanced cardiac, kidney, respiratory diseases, or other malignancies
- Unable to understand the research content
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongshan Ophthalmic Center, Sun Yat-Sen University
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
R
Rong Lu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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