Actively Recruiting
A RCT of Labor Induction at 39 Weeks in Low - Risk Women in China
Led by Women's Hospital School Of Medicine Zhejiang University · Updated on 2026-02-25
1074
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators are committed to identifying the optimal timing of delivery for low-risk pregnancies. While current guidelines typically recommend induction at 41 weeks, emerging evidence suggests that elective induction at 39 weeks may lead to improved maternal and neonatal outcomes. The U.S.-based ARRIVE trial demonstrated that induction at 39 weeks significantly reduced cesarean delivery rates compared to expectant management, and a similar randomized controlled trial (French-ARRIVE) is ongoing in France. However, population-specific evidence for the Chinese population remains lacking. This study is designed to establish a prospective cohort of low-risk pregnant women in China, comparing the effects of induction at 39 weeks, induction at 41 weeks, and expectant management on cesarean section rates and other maternal and neonatal outcomes. In addition, multi-omics technologies will be employed to analyze cord blood samples-including metabolomics and proteomics-to identify early biomarkers potentially associated with long-term child health. The study will begin with a pilot phase to assess feasibility and inform operational strategies for large-scale implementation. The ultimate goal of this project is to generate evidence tailored to the Chinese population to support more individualized decision-making, improve clinical outcomes, and enhance maternal and neonatal safety.
CONDITIONS
Official Title
A RCT of Labor Induction at 39 Weeks in Low - Risk Women in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Singleton pregnancy or twin pregnancy reduced to singleton before 14 weeks
- Gestational age between 38 weeks 4 days and 39 weeks 3 days at randomization
- Eligible for vaginal delivery with a desire for vaginal birth
- Reliable gestational age determination
- Maternal and fetal conditions assessed as favorable by at least two senior obstetricians, with no indications requiring delivery before 41 weeks
- Ability to understand study information and provide informed consent
You will not qualify if you...
- First-trimester ultrasound estimate greater than 13 weeks 6 days
- Planned induction before 41 weeks
- Planned cesarean delivery or contraindications to vaginal delivery
- Already delivered, in labor, or ruptured membranes at enrollment
- Placenta previa, vasa previa, placenta accreta, or placental abruption
- Contraindications to induction such as cervical cancer, history of uterine rupture, genital tract malformations, abnormal fetal position, or cord prolapse
- Active vaginal bleeding exceeding spotting
- History of cesarean delivery or uterine/cervical surgery
- Cervical cerclage during this pregnancy
- Maternal conditions not suitable for expectant management beyond 39 weeks, including pregestational diabetes, insulin-dependent gestational diabetes, hypertensive disorders, or intrahepatic cholestasis of pregnancy
- Fetal conditions not suitable for expectant management beyond 39 weeks, including fetal death, major anomalies, growth restriction, macrosomia, anemia, oligohydramnios, or polyhydramnios
- Maternal infections or positive screenings for sexually transmitted infections or group B Streptococcus
- Planned delivery at a non-study facility
- Participation in another intervention study affecting delivery management
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Women's Hospital School of Medicine Zhejiang University
Hangzhou, Zhejiang, China, 310006
Actively Recruiting
Research Team
H
Huajing Gao, MD Candidate
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here