Actively Recruiting
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
Led by University College, London · Updated on 2025-07-09
140
Participants Needed
1
Research Sites
422 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
S
Stryker Instruments
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control. Patients receiving the Mako robotic UKA (Stryker Ltd) will form the investigation group and those undergoing the jig-based Oxford UKA (Zimmer-Biomet Ltd) with navigation control will form the control group. The primary objective in this study is to compare accuracy of component positioning as assessed by postoperative low radiation dose CT scan between conventional Jig-based Oxford UKA with navigation control and Mako robotic UKA.
CONDITIONS
Official Title
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient has medial unicompartmental knee osteoarthritis requiring primary UKA
- Patient and surgeon agree UKA is the most appropriate treatment
- Patient is fit for surgery as reviewed by surgeon and anaesthetist
- Patient is between 40 and 80 years old at time of surgery
- Patient can give informed consent and will comply with postoperative review
- Patient is a permanent resident in an area accessible to the study site
- Patient has sufficient mobility to attend follow-up clinics and undergo radiographs
You will not qualify if you...
- Patient is not suitable for primary UKA (e.g., multi-compartmental knee osteoarthritis, anterior cruciate ligament rupture)
- Patient is not medically fit for surgery
- Patient requires revision surgery after failed correctional osteotomy or ipsilateral UKA
- Patient is immobile or has neurological conditions affecting musculoskeletal function
- Patient is younger than 40 or older than 80 years
- Patient is enrolled in another clinical trial
- Patient is unable or unwilling to sign informed consent for this study
- Patient cannot attend follow-up program
- Patient is non-resident or expected to leave the local area after surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UCL Hospital NHS Foundation Trust
London, United Kingdom, NW1 2BU
Actively Recruiting
Research Team
J
Jenni Tahmassebi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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