Actively Recruiting
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
Led by Reunion Neuroscience Inc · Updated on 2026-05-06
100
Participants Needed
28
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to cancer or other illnesses such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD) or Idiopathic Pulmonary Fibrosis (IPF) as compared to active-placebo.
CONDITIONS
Official Title
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has had Adjustment Disorder for at least 4 weeks with depressed mood or mixed anxiety and depression triggered by cancer, ALS, MS, Parkinson's Disease, or IPF
- Is ambulatory and able to care for self to complete study procedures
- Has normal cognitive function
- Is on stable antidepressant or psychotherapy treatment, or willing to delay such treatments until study end
- If female, is not pregnant or planning pregnancy; if male, is not planning to father a child
- Is willing and able to follow study requirements
You will not qualify if you...
- Has a significant risk of suicide
- Has current or past bipolar disorder, schizophrenia, schizoaffective disorder, psychotic disorder, borderline personality disorder, or a first-degree family history of psychosis or bipolar disorder
- Has active or past central nervous system cancer
- Has other serious medical conditions that make participation unsuitable
- Has used or needs to use prohibited medications or therapies
- Has known allergy or intolerance to the study drug or rescue medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 28 locations
1
UAB, Psychiatry and Behavioral Neurology
Birmingham, Alabama, United States, 35209
Actively Recruiting
2
University of Arizona
Tucson, Arizona, United States, 85724
Actively Recruiting
3
Kadima Neuropsychiatry Institute
San Diego, California, United States, 92037
Actively Recruiting
4
Providence Medical Foundation
Santa Rosa, California, United States, 95403
Actively Recruiting
5
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
6
University of South Florida, Department of Psychiatry and Behavioral Neuroscience
Tampa, Florida, United States, 33613
Actively Recruiting
7
Emory University
Atlanta, Georgia, United States, 30329
Actively Recruiting
8
Hawaii Pacific Neuroscience
Honolulu, Hawaii, United States, 96817
Actively Recruiting
9
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
10
The University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
11
LSU Health Shreveport
Shreveport, Louisiana, United States, 71103
Actively Recruiting
12
Sunstone Therapies, PC
Rockville, Maryland, United States, 20850
Actively Recruiting
13
Sheppard Pratt
Towson, Maryland, United States, 21204
Actively Recruiting
14
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
15
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
16
Henry Ford Health
Novi, Michigan, United States, 48377
Actively Recruiting
17
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
18
University of New Mexico, School of Medicine
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
19
NYU Langone Center for Psychedelic Medicine
New York, New York, United States, 10016
Actively Recruiting
20
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
21
Cleveland Clinic
Cleveland, Ohio, United States, 44113
Actively Recruiting
22
The Ohio State University, Department of Psychiatry
Columbus, Ohio, United States, 43210
Actively Recruiting
23
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
24
Alliance for Multispecialty Research Clinical
Knoxville, Tennessee, United States, 37920
Actively Recruiting
25
Dell Medical School, University of Texas at Austin
Austin, Texas, United States, 78712
Actively Recruiting
26
Cedar Clinical Research Inc.
Draper, Utah, United States, 84020
Actively Recruiting
27
UVA Center for Psychiatric Clinical Research
Charlottesville, Virginia, United States, 22903
Actively Recruiting
28
Seattle Neuropsychiatric Treatment Center
Seattle, Washington, United States, 98104
Actively Recruiting
Research Team
M
Mark Pollack, Chief Medical Officer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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