Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence

What this Trial Is About

Researchers are investigating how long-term adherence to diet affects symptoms and disease progression in people with gastroesophageal reflux disease (GERD). This study includes patients with different forms of GERD, such as non-erosive GERD, reflux-oesophagitis, and hypersensitive oesophagus, all diagnosed using modern techniques like questionnaires, endoscopy, and pH-impedance recordings. The study aims to understand the impact of diet alongside other factors such as body weight, physical activity, smoking, and medications. Participants will be observed over three years, with diet assessed using a computer-based food frequency questionnaire every three months. The study groups are formed based on changes in disease manifestations, including symptom severity and oesophagitis grade, as well as adherence to diet, physical activity changes, and use of anti-secretory medications. Data analysis will compare these factors to initial assessments to evaluate their influence on disease progression. Throughout the study, participants will undergo standard examinations and complete questionnaires to assess symptoms like heartburn frequency and severity. The primary outcomes measured include weekly heartburn frequency, daily heartburn severity, and the grade of erosive oesophagitis at two years after enrollment. Researchers will monitor participants' adherence to diet and medications, physical activity, and other health factors to understand their effects on GERD over time. The study is expected to continue until the end of 2027.

Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence