Actively Recruiting
Real-Time Diagnosis of Eosinophilic Nasal Polyps Using High-Sensitivity Spectroscopy
Led by The Affiliated Hospital of Qingdao University · Updated on 2025-12-30
353
Participants Needed
1
Research Sites
144 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common condition causing nasal congestion, discharge, and reduced sense of smell, seriously affecting patients' quality of life. A subtype called eosinophilic CRSwNP (eCRSwNP) is difficult to treat and often recurs after surgery. Currently, diagnosing this subtype requires tissue samples after surgery, which delays treatment decisions and may lead to unnecessary surgeries. Our research team has developed a new, non-invasive diagnostic system using advanced spectral technology to detect a natural fluorescence marker inside eosinophils (a type of immune cell) in nasal polyps. This system can quickly identify eCRSwNP before surgery by shining a safe light on the nasal tissue and analyzing the fluorescence signals. This study aims to evaluate how accurate and safe this real-time diagnostic system is in clinical practice. If successful, it will help doctors choose better personalized treatments, reduce unnecessary surgeries, lower recurrence rates, and ultimately improve patients' lives.
CONDITIONS
Official Title
Real-Time Diagnosis of Eosinophilic Nasal Polyps Using High-Sensitivity Spectroscopy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female subjects aged 18 to 65 years old
- Diagnosed with chronic rhinosinusitis with nasal polyps (CRSwNP) by nasal endoscopy, CT, or MRI before surgery
- Normal blood clotting test results including prothrombin time, activated partial thromboplastin time, and platelet count
- No severe heart or lung problems or other conditions that would affect tolerance to general anesthesia and surgery
- Women of childbearing age agree to use effective contraception during the study and for 4 weeks after
- Good compliance and voluntary participation with signed informed consent
You will not qualify if you...
- Other nasal or sinus diseases besides chronic rhinosinusitis, such as nasal tumors, fungal sinusitis, or nasal deformities from injury
- Blood clotting problems, immune system deficiencies, current use of blood thinners or antiplatelet drugs, or menstruating females at the time of visit
- Use of oral glucocorticoids within 1 month before the visit
- History of nasal endoscopic surgery or nasal radiotherapy
- Pregnancy, breastfeeding, or severe systemic diseases like uncontrolled high blood pressure, diabetes, liver or kidney failure
- Missing clinical data or incomplete follow-up after surgery
- Any other condition that the researcher believes makes participation unsuitable
- Poor compliance with treatment or study procedures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Affiliated Hospital of Qingdao University
Qingdao, Shandong, China, 266003
Actively Recruiting
Research Team
Y
Yan Jiang, MD
CONTACT
S
Shunke Li, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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