Actively Recruiting
Real Time Molecular Analysis of Breast Cancer Receiving Neo-adjuvant Chemotherapy
Led by Institut Paoli-Calmettes · Updated on 2025-06-15
150
Participants Needed
1
Research Sites
373 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The present project aims at identifying robust candidates for drug resistance in BC patients eligible for NAC. Its originality lies upon the combination of three different and complementary prospective approaches: from the molecular analyses of biopsies sampled before and after NAC, from in vitro BC Patient-Derived Organoids (PDO) mimicking patient's response to NAC, and from Circulating Tumor Cells (CTCs) isolated before/during/after NAC.
CONDITIONS
Official Title
Real Time Molecular Analysis of Breast Cancer Receiving Neo-adjuvant Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Woman over 18
- Signed consent to participate
- Histologically or cytologically confirmed invasive mammary adenocarcinoma
- Indication for neo-adjuvant chemotherapy by clinical team
- No contraindication to neo-adjuvant chemotherapy
- Planned surgery and radiotherapy after neo-adjuvant chemotherapy
- Performance status of 0 or 1 (WHO scale)
- Affiliated with or beneficiary of a social security scheme
You will not qualify if you...
- Planned treatment including neo-adjuvant radiotherapy before surgery
- Metastatic breast cancer at diagnosis
- Previous breast cancer relapse
- Other cancer within the past 3 years except treated low-risk cancers
- Pregnant, likely to be pregnant without effective contraception, or breastfeeding
- Under legal protection or unable to give consent
- Unable to attend medical follow-up due to geographical, social, or psychological reasons
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Trial Site Locations
Total: 1 location
1
Institut Paoli-Calmettes
Marseille, Marseille, France, 13009
Actively Recruiting
Research Team
J
j PAKRADOUNI, PharmD,PhD
CONTACT
L
Laurie-Anne GOUTY, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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