Actively Recruiting
Real-time Personalized Brain State-dependent TMS After Stroke
Led by Sara Hussain · Updated on 2026-02-03
37
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
S
Sara Hussain
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and upper extremity motor impairment.
CONDITIONS
Official Title
Real-time Personalized Brain State-dependent TMS After Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of residual upper extremity hemiparesis defined by any of the following: Fugl-Meyer Upper Extremity Score less than 66, Wolf Motor Function Test Score less than 70, affected hand performance on the 9-Hole Peg Test at least 10% worse than unaffected hand, affected hand pinch, key, or power grip performance at least 10% worse than unaffected hand
- Stroke occurred at least 6 months prior to participation
- Mini Mental State Exam score greater than 24
- Willingness and ability to provide informed consent
- No history of neurological disease or injury other than stroke
- Presence of residual corticospinal connections to an affected upper extremity muscle following stimulation of the lesioned hemisphere (MEP positive) evaluated at rest
You will not qualify if you...
- Any contraindications to TMS, including cardiac pacemaker, cochlear implant, cortical stimulator, deep brain stimulator, vagus nerve stimulator, cervical spine epidural stimulation, ventriculoperitoneal shunt, ferromagnetic metallic implants above the seventh cervical vertebra
- Seizure in the last 12 months while taking anti-epilepsy medication
- History of adverse reactions to TMS or peripheral nerve stimulation
- Current, suspected, or planned pregnancy
- Any recent changes (within the last month) to medication use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
S
Sara J Hussain, PhD
CONTACT
S
Sara J Hussain, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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