Challenges for quality and utilization of real-world data for diffuse large B-cell lymphoma in REALYSA, a LYSA cohort.
Hervé Ghesquières, Fanny Cherblanc, Aurélien Belot...
https://pubmed.ncbi.nlm.nih.gov/37874913Actively Recruiting
Age: 18Years +
All Genders
ID03869619
REAL WORLD DATA IN LYMPHOMA AND SURVIVAL IN ADULTS
Led by Hospices Civils de Lyon · Updated on 2021-06-28
6000
Participants Needed
37
Research Sites
N/A
Total Duration
On this page
Sponsors
H
Hospices Civils de Lyon
Lead Sponsor
T
The Lymphoma Academic Research Organisation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying lymphoma in adults to better understand prognostic factors by combining epidemiological, clinical, and biological data. The study focuses on seven subtypes of lymphoma and aims to identify causes of treatment resistance and relapse, monitor long-term health effects, and assess quality of life and second cancers in survivors. This observational platform also looks at how treatments work in real life and explores socio-economic issues related to lymphoma. Participants diagnosed with lymphoma within the last six months and who consent to join the REALYSA cohort provide data for this study. There is no treatment given as part of this observational study; instead, data about the patients' lymphoma subtype, treatments received, and outcomes are collected and analyzed over time. Patients are included from various regions and lymphoma subtypes to create a comprehensive database. During the study, researchers collect ongoing information about patients’ health, treatments, and disease progression. They measure outcomes such as progression-free survival over five years and record events like second cancers and chronic diseases. The study tracks patients’ response rates, survival, and frequency of lymphoma transformations. Participants are followed long-term to better understand lymphoma outcomes and quality of life.
CONDITIONS
Brief Title
REal World Data in LYmphoma and Survival in Adults
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Signed consent form to participate in the REALYSA cohort
- Age 18 years or older at time of inclusion
- Diagnosed with lymphoma within the last 6 months (180 days)
- Lymphoma subtype is one of: diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, T-cell lymphoma, Hodgkin's lymphoma, or Burkitt lymphoma
You will not qualify if you...
- Received anti-lymphoma treatment already, except pre-phase treatments like corticosteroids, vincristine, cyclophosphamide, or etoposide
- Documented HIV infection
- Diagnosed with any lymphoma subtype not included in the approved list, such as chronic lymphocytic leukemia, hairy cell leukemia, lymphoplasmacytic lymphoma, Waldenström macroglobulinemia, primary CNS DLBCL, T-cell large granular lymphocytic leukemia, chronic NK cell disorder, mycosis fungoides, Sézary syndrome, primary cutaneous T cell lymphomas, or post-transplant lymphoproliferative disorders (PTLD)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 9 years
Participants are observed over several years to collect data on lymphoma progression, survival, and related health outcomes.
Periodic visits as determined by routine care and study protocol
Trial Site Locations
Total: 37 locations
1
Unité d'Hématologie Clinique, CH D'ARRAS
Arras, France, 62022
Actively Recruiting
2
Service d'Hématologie, CHU Jean Minjoz
Besançon, France, 25030
Actively Recruiting
3
Service d'Onco-radiolothérapie, Polyclinique Bordeaux Nord Aquitaine
Bordeaux, France, 33300
Actively Recruiting
4
Institut Bergonié
Bordeaux, France
Actively Recruiting
5
Centre Hospitalier Pierre Oudot
Bourgoin, France, 38302
Actively Recruiting
6
Service d'Hématologie, Institut d'Hématologie de Basse Normandie
Caen, France, 14000
Actively Recruiting
7
METROPOLE SAVOIE - SITE CHAMBERY, place Lucien Biset,
Chambéry, France, 73000
Actively Recruiting
8
Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Estaing, CHU de Clermont-Ferrand
Clermont-Ferrand, France, 63000
Actively Recruiting
9
Unité Hémopathies Lymphoïdes, Hôpital Henri Mondor
Créteil, France, 94010
Actively Recruiting
10
CHU Francois MITTERRAND
Dijon, France
Actively Recruiting
11
Service Hématologie, Centre Hospitalier de Dunkerque
Dunkirk, France, 59140
Actively Recruiting
12
Service Oncologie médicale, Groupe Hospitalier Mutualiste de Grenoble, Institut Daniel Hollard,
Grenoble, France, 38028
Actively Recruiting
13
CHD Vendée
La Roche-sur-Yon, France
Actively Recruiting
14
Service d'Hématologie Clinique, Centre Hospitalier Universitaire Michallon
La Tronche, France, 38700
Actively Recruiting
15
Clinique Victor Hugo
Le Mans, France, 72000
Actively Recruiting
16
Centre hospitalier Libourne
Libourne, France, 33500
Actively Recruiting
17
Service Oncologie médicale, HOPITAL SAINT VINCENT-DE-PAUL
Lille, France, 59020
Actively Recruiting
18
Service des maladies du sang, Hôpital Claude Huriez, CHRU de Lille
Lille, France, 59037
Actively Recruiting
19
Service Hématologie Clinique et Thérapie Cellulaire, CHU DE LIMOGES - HOPITAL DUPUYTREN,
Limoges, France, 87042
Actively Recruiting
20
Département d'Hématologie et Oncologie, Centre Léon Bérard
Lyon, France, 69008
Actively Recruiting
21
Département d'Hématologie Clinique, Hôpital Saint-Eloi,
Montpellier, France, 34295
Actively Recruiting
22
Service Hématologie, GH REGION MULHOUSE ET SUD ALSACE - HOPITAL EMILE MULLER,
Mulhouse, France, 68070
Actively Recruiting
23
Service d'Hématologie clinique, Centre Hospitalier Universitaire de Nantes
Nantes, France, 44093
Actively Recruiting
24
Centre Hospitalier de Niort
Niort, France, 79021
Actively Recruiting
25
Service Hématologie, Hôpital St Louis
Paris, France, 75475
Actively Recruiting
26
CHU Haut-Lévêque
Pessac, France
Actively Recruiting
27
Centre Hospitalier Lyon Sud
Pierre-Bénite, France
Actively Recruiting
28
Service d'Hématologie et Thérapie Cellulaire, Centre Hospitalier Universitaire de Poitiers
Poitiers, France, 86021
Actively Recruiting
29
Hématologie Clinique, CHU PONTCHAILLOU
Rennes, France, 35033
Actively Recruiting
30
Service Hématologie, Centre Hospitalier de Roubaix - Hôpital Victor Provo
Roubaix, France, 59056
Actively Recruiting
31
Service Hématologie, UNIVERSITE DE ROUEN, CENTRE HENRI BECQUEREL
Rouen, France, 76038
Actively Recruiting
32
Service Hématologie, CH YVES LE FOLL
Saint-Brieuc, France, 22027
Actively Recruiting
33
Service Hématologie, Institut Curie - Hôpital René HUGUENIN
Saint-Cloud, France, 92210
Actively Recruiting
34
Département d'Hématologie Clinique et Thérapie Cellulaire, Institut de Cancérologie Lucien Neuwirth
Saint-Priest-en-Jarez, France, 42270
Actively Recruiting
35
Hôpitaux Universitaires de Strasbourg
Strasbourg, France
Actively Recruiting
36
Institut Universitaire du Cancer
Toulouse, France
Actively Recruiting
37
Hématologie Clinique, CH DE BRETAGNE ATLANTIQUE
Vannes, France, 56017
Actively Recruiting
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Research Team
H
Hervé Ghesquières, MD
A
Alain Monnereau, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
A French multicentric prospective prognostic cohort with epidemiological, clinical, biological and treatment information to improve knowledge on lymphoma patients: study protocol of the "REal world dAta in LYmphoma and survival in adults" (REALYSA) cohort.
Hervé Ghesquières, Cédric Rossi, Fanny Cherblanc...
https://pubmed.ncbi.nlm.nih.gov/33653294