Actively Recruiting
Real-World Effectiveness of Benralizumab in Allergic Bronchopulmonary Aspergillosis
Led by Qianfoshan Hospital · Updated on 2026-04-21
20
Participants Needed
2
Research Sites
65 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
An open-label study will evaluate effects of Benralizumab in the treatment of severe asthma in patients with allergic bronchopulmonary aspergillosis
CONDITIONS
Official Title
Real-World Effectiveness of Benralizumab in Allergic Bronchopulmonary Aspergillosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients aged 18 to 75 years
- Physician diagnosis of Allergic Bronchopulmonary Aspergillosis meeting ISHAM criteria
- Predisposing bronchial asthma
- Positive Aspergillus skin test or elevated specific IgE to Aspergillus fumigatus, niger, or flavus
- Elevated total IgE levels (>1,000 IU/mL) or acceptable lower levels with other criteria
- At least two of three: precipitating IgG antibodies to Aspergillus, radiographic lung opacities, or eosinophil count >500 cells/uL in steroid-naive patients
- Severe chronic asthma for at least 12 months requiring high-dose inhaled corticosteroids plus an asthma controller
- Current treatment with high daily doses of inhaled corticosteroids (>500ug fluticasone propionate equivalent) plus another asthma controller for at least 3 months
- History of at least 2 asthma exacerbations requiring systemic corticosteroids in the past 12 months
- Weight over 40 kg
You will not qualify if you...
- Significant lung diseases other than asthma with ABPA (e.g., COPD, cystic fibrosis, sarcoid, pulmonary fibrosis)
- History of anaphylaxis to any biologic therapy
- Known allergy or hypersensitivity to benralizumab or its components
- Current smokers or former smokers with over 10 pack-years smoking history
- Pregnant, breastfeeding, or lactating women
- Participation in another interventional or post-authorization safety study unless observational
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, #16766, Jingshi Road, Jinan City, Shandong Province, China
Jinan, Shandong, China, 250014
Actively Recruiting
2
Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University
Jinan, Shandong, China, 250014
Actively Recruiting
Research Team
Q
Qian Qi, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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