Actively Recruiting
Real-World NeuroModulate: Investigating Non-Invasive Brain Stimulation for Neuropsychiatric Disorders at TUM
Led by Technical University of Munich · Updated on 2026-02-19
100
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study, patients diagnosed with a depressive syndrome and with a clinical indication for treatment will receive an acute course of transcranial magnetic stimulation (TMS). The treatment consists of 20 TMS sessions administered over a period of four weeks (five sessions per week). Magnetic resonance imaging (MRI) will be performed at four time points: prior to the start of treatment, after 10 treatment sessions, after completion of all 20 sessions, and at a three-month follow-up after the end of treatment. The MRI data will include different imaging modalities to assess treatment-related neurobiological changes. The primary objective is to investigate changes in neuroimaging markers over the course of TMS treatment and to examine their associations with clinical response and behavioral as well as clinical outcome measures. Another key goal of the study is the identification of markers allowing for early prediction of treatment response to TMS and, additionally, for the prediction of relapse at follow-up.
CONDITIONS
Official Title
Real-World NeuroModulate: Investigating Non-Invasive Brain Stimulation for Neuropsychiatric Disorders at TUM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Clinical indication for non-invasive brain stimulation due to a depressive episode or predominant depression-associated symptoms
- Insufficient response to first-line treatments and/or preference for brain stimulation treatment
- Capacity and willingness to provide written informed consent
You will not qualify if you...
- Acute suicidal risk
- Presence of significant neurological disorders including increased intracranial pressure, space-occupying brain lesions, or recent cerebrovascular accident within 12 months
- Incidental structural brain abnormalities on MRI needing further diagnostic clarification
- Non-removable ferromagnetic implants near the stimulation site (e.g., cochlear implants, implanted neurostimulators, metallic clips or nails)
- Other treatment-relevant ferromagnetic implants such as cardiac pacemakers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Technical University of Munich
München, Germany, 81675
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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