Actively Recruiting
A Real-world Observational Study of a Mucosal Contouring Method for Radiation-induced Oropharyngeal Mucositis
Led by Nanfang Hospital, Southern Medical University · Updated on 2024-03-13
718
Participants Needed
10
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The performance of the predictive models for the occurrence and severity of oropharyngeal mucositis established using either oral cavity contouring method or mucosa surface contouring method was unsatisfactory in nasopharyngeal carcinoma (NPC). Whereas the predictive model of a mucosal contouring method based on swallowing-induced breakthrough pain exhibited better overall performance in locally advanced NPC. Therefore, the investigators aimed to conduct a prospective, multicenter, real-world observational study to further assess the predictive efficacy of this mucosal delineation method for radiation-induced oropharyngeal mucositis in NPC.
CONDITIONS
Official Title
A Real-world Observational Study of a Mucosal Contouring Method for Radiation-induced Oropharyngeal Mucositis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide informed written consent.
- Age 18 years or older.
- Histologically confirmed nasopharyngeal carcinoma.
- Currently undergoing radical radiotherapy or chemoradiotherapy.
- Complete and continuous records of oral or oropharyngeal mucositis grading and self-reported swallowing-induced breakthrough pain.
You will not qualify if you...
- Poor oral hygiene, untreated dental or periodontal diseases, or metal dental restorations.
- Untreated or unresolved unstable heart diseases requiring treatment.
- Poorly controlled diabetes mellitus.
- Body mass index (BMI) less than 18.5.
- Considered unsuitable for participation by researchers.
AI-Screening
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Trial Site Locations
Total: 10 locations
1
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Guangzhou, Guangdong, China
Not Yet Recruiting
2
Nanfang hospital, Southern medical university
Guangzhou, Guangdong, China
Actively Recruiting
3
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China
Not Yet Recruiting
4
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Not Yet Recruiting
5
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Not Yet Recruiting
6
Yuebei People's Hospital
Shaoguan, Guangdong, China
Not Yet Recruiting
7
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
Not Yet Recruiting
8
The Fifth Affiliated Hospital, Sun Yat-sen University
Zhuhai, Guangdong, China
Not Yet Recruiting
9
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Not Yet Recruiting
10
Sichuan Cancer Hospital
Chengdu, Sichuan, China
Not Yet Recruiting
Research Team
J
Jian Guan, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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