Comparing Different Treatments for Early Missed Abortion in Women Aged 18 to 40

What this Trial Is About

Researchers are studying different treatments for early missed abortion, a condition where the pregnancy fails but is not immediately expelled. This study aims to compare the effectiveness of surgical and medical approaches, including how different doses of estrogen might improve outcomes and reduce complications. It includes both a retrospective analysis and a prospective study to find the best treatment method for early missed abortion. The trial involves several treatment groups one receiving surgery without estrogen, another undergoing surgery with estrogen before the procedure, and two medical treatment groups using mifepristone combined with misoprostol, with or without added estrogen. Surgery is performed under ultrasound guidance or laparoscopically with general anesthesia, while medication is given in specific doses and repeated if needed. Estrogen is administered orally for several days in the estrogen groups. Participants will be closely monitored through clinical exams, ultrasound, and laboratory tests. The main outcomes measured include the rate of complete abortion within 14 days, presence of intrauterine adhesions three months after treatment, and reproductive outcomes up to one year after treatment. Other evaluations include blood loss during surgery, time to expel pregnancy tissue with medication, adverse reactions, menstrual changes, and residual tissue after treatment. Follow-up visits occur at defined intervals to assess these outcomes over time.

A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion