Actively Recruiting
A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion
Led by The Third Xiangya Hospital of Central South University · Updated on 2026-02-20
580
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying different treatments for early missed abortion, a condition where the pregnancy fails but is not immediately expelled. This study aims to compare the effectiveness of surgical and medical approaches, including how different doses of estrogen might improve outcomes and reduce complications. It includes both a retrospective analysis and a prospective study to find the best treatment method for early missed abortion. The trial involves several treatment groups: one receiving surgery without estrogen, another undergoing surgery with estrogen before the procedure, and two medical treatment groups using mifepristone combined with misoprostol, with or without added estrogen. Surgery is performed under ultrasound guidance or laparoscopically with general anesthesia, while medication is given in specific doses and repeated if needed. Estrogen is administered orally for several days in the estrogen groups. Participants will be closely monitored through clinical exams, ultrasound, and laboratory tests. The main outcomes measured include the rate of complete abortion within 14 days, presence of intrauterine adhesions three months after treatment, and reproductive outcomes up to one year after treatment. Other evaluations include blood loss during surgery, time to expel pregnancy tissue with medication, adverse reactions, menstrual changes, and residual tissue after treatment. Follow-up visits occur at defined intervals to assess these outcomes over time.
CONDITIONS
Brief Title
A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-40 years old
- Confirmed early pregnancy missed abortion by imaging and laboratory tests
- Normal results in routine examinations with no serious systemic diseases
- No urgent need for curettage
- Willingness and ability to comply with follow-up visits (for prospective study)
You will not qualify if you...
- Contraindications to medical abortion
- Allergy or contraindications to estrogen
- Inability to follow up as required
- History or suspicion of thromboembolic diseases, breast cancer, hormone-dependent tumors
- Vaginal bleeding exceeding normal menstrual volume
- Severe heart, liver, or kidney diseases
- Serious internal or surgical diseases, malignant tumors, or mental illnesses preventing cooperation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 14 days after initiation of treatment
Participants receive one of several treatment regimens for early missed abortion, including medical abortion with medication or surgical abortion, followed by estrogen supplementation cycles as applicable.
1 to 2 visits depending on treatment type
Duration - Up to 1 year after treatment completion
Participants are monitored for intrauterine adhesions and menstrual changes, and pregnancy outcomes are tracked for up to one year after treatment completion.
Approximately 3 visits over 3 months and additional visits as needed up to 1 year
Trial Site Locations
Total: 1 location
1
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China, 410013
Actively Recruiting
Research Team
D
Dabao Xu
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here