Actively Recruiting
A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-01-06
90
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if fecal microbiota transplantation can treat in Gastrointestinal cancer patients with chemotherapy / targeted gastrointestinal symptoms. The main question it aims to answer is: To evaluate the effect of fecal microbiota transplantation (FMT) on gastrointestinal tract in patients with gastrointestinal tumors.
CONDITIONS
Official Title
A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Estimated survival time of 3 months or more
- Confirmed diagnosis of gastrointestinal tumors by pathology, including esophageal, gastric, colon, or rectal cancer
- Cancer at Stage IV according to TNM staging
- Completed PD-1 or PD-L1 testing
- Planned to receive the 4th cycle of chemotherapy or targeted therapy
- Experienced gastrointestinal side effects such as diarrhea, constipation, vomiting, or nausea within the first 3 cycles of chemotherapy or targeted therapy
- Able and willing to provide informed consent and complete follow-up
- Eastern Cooperative Oncology Group (ECOG) Performance Status score of 1 to 3
- Use of broad-spectrum antibiotics within 3 days should be cautious
- Able to swallow capsules without chewing
- Laboratory tests during screening show adequate organ function
You will not qualify if you...
- Major organ dysfunction or failure including heart, kidney, or liver problems
- Uncontrolled or severe infections
- History of psychotropic substance abuse, alcoholism, or drug abuse
- Severe infections with septicemia or sepsis
- History of severe allergic reactions or allergy to components of bacterial capsules
- Active viral infections
- Positive pregnancy test, lactating women, or women of childbearing age not using contraception during the 15-week observation period
- Gastrointestinal perforation or fistula
- Any other conditions the investigator considers unsuitable for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital Zhejiang University School of Medicine
Zhejiang, Hangzhou, China, 310009
Actively Recruiting
Research Team
D
Da Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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