Actively Recruiting
REALITY MONITORING
Led by Hôpital le Vinatier · Updated on 2025-03-06
39
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease. The investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.
CONDITIONS
Official Title
REALITY MONITORING
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers who have given their written informed consent
- Men and women from 18 to 45 years old
- Normal or corrected vision
- Being fluent in French or French as native language
- Being affiliated with health insurance
You will not qualify if you...
- Inadmissibility of the subject's consent or refusal
- Working-memory deficit (MMSE score < 23)
- Any past or current psychiatric or somatic condition (as controlled with the Mini International Neuropsychiatric Interview, MINI)
- Any past or current neurological condition
- History of cranio-cerebral trauma, arterial hypotension or hypertension, cardiological or serious medical condition
- Abnormal potassium dosage (below 3.1 mmol/L or above 4.9 mmol/L)
- Abnormal ECG
- History of schizophrenia or bipolar disorder in first-degree relatives
- Alcohol-drinking and caffeine intake at least during 24 hours before each session
- Drug therapy except contraceptives
- Cardiologic or severe medical condition
- Pregnancy (checked with a pregnancy autotest), lactation, or insufficient contraceptive measure
- Consumption of recreational drugs during the last 6 months
- Known sensitivity to any of the study medication and their excipients
- Lactose intolerance
- Porphyria
- Hepatic insufficiency
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier le Vinatier
Bron, France, 69678
Actively Recruiting
Research Team
J
JEROME BRUNELIN
CONTACT
V
VERONIQUE VIAL
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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