Actively Recruiting
RECOMMEND Platform Trial
Led by Australian and New Zealand Intensive Care Research Centre · Updated on 2026-05-13
600
Participants Needed
3
Research Sites
166 weeks
Total Duration
On this page
Sponsors
A
Australian and New Zealand Intensive Care Research Centre
Lead Sponsor
M
Monash University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main question the platform trial aims to address is to determine the effect of a range of interventions on survival, organ support and resource utilisation to day 28 for hospitalised patients receiving ECMO. Researchers will compare various interventions within multiple platform trial domains to see if the interventions have effects on survival, organ support and resource utilisation for the patient cohort. Participants will be enrolled in accordance with the platform trial's domain structure to answer the research questions.
CONDITIONS
Official Title
RECOMMEND Platform Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients receiving ECMO
- Patients enrolled in the EXCEL Registry - NCT03793257
- Aged 18 years or older
You will not qualify if you...
- Treating clinician regards death as imminent and inevitable
- Treating clinician determines it is not in the patient's best interests
- Contraindication to RBC transfusion (including known patient preference)
- Limitations of care put in place either through patient wishes or the treating medical teams
- Participant has already received ECMO >12 hours
- The treating physician anticipates that ECMO treatment will cease before the end of tomorrow
- The treating physician deems the study is not in the patient's best interest
- The treating physician has concern regarding patient ability to tolerate restrictive or liberal transfusion trigger thresholds
- Actively listed for a solid organ transplant and has not yet received one
- Suspected or confirmed to be pregnant
- Previous ECMO treatment during the same hospital admission
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
Not Yet Recruiting
2
St. Vincent's Hospital Sydney
Sydney, New South Wales, Australia, 2010
Actively Recruiting
3
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Not Yet Recruiting
Research Team
C
Curtis Hopkins, B.BioMed, MPH, MHA
CONTACT
C
Carol Hodgson, PhD FACP FAHMS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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