Actively Recruiting
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
Led by Medical University of South Carolina · Updated on 2025-09-02
30
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
C
Columbia University
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this research study, the investigators are examining how brain activity (electrical and blood flow) changes during tests of emotional processing, attention and memory in the magnetic resonance imaging (MRI) scanner and outside the MRI using functional near-infrared spectroscopy (fNIRS). Investigators are also using non-invasive brain stimulation to probe different parts of the brain and measuring brain activity (electrical and blood flow). Study 1 This study includes healthy participants and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression. Study 2 This study includes participants with depression and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression.
CONDITIONS
Official Title
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Age 18-65
- For healthy participants: good health with no history of mental or physical illness or implanted metal
- For participants with depression: current depression with HAM-D scores 65 17 and no history of psychosis or mania
- English as a primary language
- Capacity to consent
- Negative urine pregnancy test if female of childbearing potential
- Willingness to adhere to the study schedule and assessments
You will not qualify if you...
- Any current psychiatric diagnosis or Clinical Global Impression rating of psychiatric illness > 1 (for healthy participants)
- Neurodevelopmental disorders, history of CNS disease, concussion, overnight hospitalization, or other neurological conditions such as tumors, seizures, meningitis, encephalitis, or abnormal brain imaging
- Any head trauma resulting in loss of consciousness
- Visual impairment (except the use of glasses)
- Inability to complete cognitive testing
- Active participation or plans for enrollment in clinical trials affecting psychosocial function
- Repeated abuse or dependence on drugs (excluding nicotine and caffeine) or use of stimulants, modafinil, thyroid medication, or steroids
- Implanted devices or ferrous metal of any kind
- History of seizure or epilepsy or currently taking medications that lower seizure thresholds
- Claustrophobia or conditions preventing MRI assessment
- Pregnancy or plans to become pregnant in the short term
- Inability to adhere to the treatment schedule
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical Univeristy of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
L
Lisa McTeague, PhD
CONTACT
J
Jacob Eade, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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