Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06850844

Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients

Led by Nguyen Dang Thu · Updated on 2025-02-27

70

Participants Needed

1

Research Sites

73 weeks

Total Duration

On this page

Sponsors

N

Nguyen Dang Thu

Lead Sponsor

B

Bach Mai Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays. However, the use of intraoperative pneumoperitoneum and general anesthesia with mechanical ventilation may lead to postoperative pulmonary complications, such as atelectasis. This condition can result in diminished respiratory mechanics and impaired gas exchange. In recent years, intraoperative lung-protective mechanical ventilation techniques, including recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) strategies, have gained popularity. These approaches aim to prevent the repeated collapse and reopening of alveoli, thereby reducing the risk of atelectasis. Nonetheless, determining the optimal PEEP level for individual patients remains a complicated and unresolved issue. Electrical impedance tomography (EIT) is a bedside imaging technique that assesses regional ventilation distribution, providing a method for personalizing PEEP settings in mechanically ventilated patients. By addressing the competing risks of alveolar overdistension and collapse, EIT enhances the precision of PEEP titration. This study aims to compare the effects of recruitment maneuvers and EIT-guided PEEP selection against conventional ventilation on regional ventilation, gas exchange, and pulmonary mechanics in patients undergoing abdominal laparoscopic surgery.

CONDITIONS

Official Title

Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age > 18 years
  • Scheduled for abdominal laparoscopy surgery
  • At increased (intermediate or high) risk of postoperative pulmonary complications with ARISCAT score ≥ 26 points
  • Signed written informed consent
Not Eligible

You will not qualify if you...

  • Major previous lung surgery (e.g., lung resection)
  • Severe chronic obstructive pulmonary disease and/or severe emphysema
  • Increased intracranial pressure
  • Contraindications for EIT (pacemakers, defibrillators, chest trauma, or recent chest surgery limiting EIT belt use)
  • Presence of undrained or new pneumothorax
  • Unstable hemodynamics with mean arterial pressure < 60 mmHg unresponsive to treatment, and/or heart rate < 60 bpm
  • Pregnancy
  • Severe neuromuscular disease

AI-Screening

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Trial Site Locations

Total: 1 location

1

Anesthesia Center, Bach Mai Hospital

Hanoi, Vietnam, 10000

Actively Recruiting

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Research Team

T

Thanh Huyen Thi Pham, M.D

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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