Actively Recruiting
Rectal Arterial Embolization vs Band Ligation for the Treatment of Internal hemOrrhoidS
Led by Jessica K. Stewart, MD · Updated on 2026-05-08
40
Participants Needed
1
Research Sites
283 weeks
Total Duration
On this page
Sponsors
J
Jessica K. Stewart, MD
Lead Sponsor
T
Terumo Medical Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to compare two standard of care non-surgical treatments for hemorrhoidal bleeding: hemorrhoidal artery embolization (HAE) versus rubber band ligation (RBL). Directly comparing these two methods may help to clarify which treatment is better for controlling hemorrhoidal bleeding, reducing symptoms, and improving patients' quality of life. HAE is a standard minimally invasive procedure to put tiny particles or coils into the blood vessel that feeds a hemorrhoid to block the blood flow (embolization). This involves using a catheter inserted into an artery, using twilight (conscious) sedation. RBL is a standard procedure that involves using small rubber bands around the base of the hemorrhoids to cut off blood flow, causing it to shrink or shrivel.
CONDITIONS
Official Title
Rectal Arterial Embolization vs Band Ligation for the Treatment of Internal hemOrrhoidS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and less than 90 years
- Ability to provide written informed consent
- Clinical history of chronic bleeding from internal hemorrhoids
- Presence of Goligher grade II-III internal hemorrhoids
- Failed conservative treatment such as fiber supplements, topical ointments, dietary changes, stool softeners, or warm baths
- Ability to comply with all treatments and follow-up visits as determined by the principal investigator
You will not qualify if you...
- Moderate kidney function loss with estimated glomerular filtration rate below 45 mL/min
- Significant arterial atherosclerosis limiting angiography
- Known other causes of gastrointestinal bleeding
- Allergy to iodinated contrast agents
- Active infection or cancer
- Pregnancy
- Nicotine use within the last 12 months
- Portal hypertension or rectal varices
- Uncorrectable bleeding disorders (INR > 2; platelet count < 100,000; PTT > 40 seconds)
- Abnormal findings on baseline CT angiography affecting treatment such as stenosis, occlusion, or hypoplasia of rectal arteries as judged by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
A
Aniket Joglekar, MD
CONTACT
S
Saima Chaabane, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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