Actively Recruiting
Rectal Cancer Neoadjuvant Therapy-Real World Study
Led by Beijing Friendship Hospital · Updated on 2026-05-05
869
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to utilise a real-world data platform to integrate multi-omics data-including radiomics, gut microbiota, pathological quality control and liquid biopsy-to construct a multidimensional predictive model for the efficacy of rectal cancer treatment following neoadjuvant therapy. By integrating multimodal data, the study aims to accurately assess the efficacy of neoadjuvant therapy and identify patients suitable for a 'watch-and-wait' strategy, thereby achieving tumour control and preserving organ function without the need for surgery. Furthermore, it seeks to provide scientific evidence for the efficacy of the 'watch-and-wait' strategy and the selection of optimal timing for surgery, whilst validating the model's effectiveness and assessing its clinical feasibility through prospective clinical trials.
CONDITIONS
Official Title
Rectal Cancer Neoadjuvant Therapy-Real World Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The patient is informed and has provided written informed consent
- Rectal adenocarcinoma confirmed by colonoscopic biopsy and pathology
- Clinical stage II/III locally advanced rectal cancer (cT1-4aN0-2M0)
- Tumor distal edge is 10 cm or less from the anal verge as measured by MRI
- No distant metastasis
- Scheduled to receive neoadjuvant therapy
- Age 18 years or older, male or female
You will not qualify if you...
- Presence of distant organ metastasis
- Multiple primary colorectal cancers
- History of prior malignancy except completely cured carcinoma in situ of the cervix, basal cell carcinoma, or squamous cell carcinoma of the skin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Friendship Hospital
Beijing, Beijing Municipality, China, 100050
Actively Recruiting
Research Team
H
hongwei Yao, Professor, Doctoral Degree
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here