Actively Recruiting
Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Led by Peking Union Medical College Hospital · Updated on 2025-06-15
1504
Participants Needed
17
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute pancreatitis (AP) is an inflammatory condition of the pancreas following the activated pancreatic enzymes induced by varied causes, with or without other organ(s) dysfunction. The production and release of inflammatory factors is generally considered as the key factor of pathogenesis. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly applied agents for inflammatory diseases. A series studies have proved that indomethacin can reduce the risk of post-endoscopic retrograde cholangiopancreatography (ERCP), but high-quality evidence is still lacking in the field of effectiveness of NSAIDs to treat, rather than prevent, other types of AP. Majority of animal experiments showed that NSAIDs had protective effects for organ functions, but the results of several preliminary clinical studies were inconsistent. Randomized controlled trials are eagerly awaited to elucidate its effects on AP.
CONDITIONS
Official Title
Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 80 years
- Diagnosis of acute pancreatitis confirmed by at least two of the following: characteristic abdominal pain, serum amylase or lipase three times above normal, or typical CT scan findings
You will not qualify if you...
- Onset of symptoms more than 24 hours prior
- Renal dysfunction with serum creatinine above 1.5 times the normal upper limit
- Severe liver dysfunction
- Active peptic ulcer disease or gastrointestinal bleeding
- Pregnancy or breastfeeding
- Allergy or hypersensitivity to NSAIDs
- New or uncontrolled high blood pressure
- Serious cardiovascular events such as severe heart failure, myocardial infarction, or stroke
- Mental disability
- Acute pancreatitis caused by cancer
- Pancreatitis following ERCP procedure
- Lack of signed informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
Peking University Sixth Hospital
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
2
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
3
Liangxiang Hospital
Beijing, Beijing Municipality, China, 102401
Actively Recruiting
4
Guiyang Second People's Hospital
Guiyang, Guizhou, China, 550005
Actively Recruiting
5
Baoding Seventh Hospital
Baoding, Hebei, China, 071000
Actively Recruiting
6
Fourth Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150001
Actively Recruiting
7
Dengzhou People's Hospital
Dengzhou, Henan, China, 411381
Actively Recruiting
8
Second People Hospital of Nanyang
Nanyang, Henan, China, 473012
Actively Recruiting
9
The Second People's Hospital of Huai'an
Huaian, Jiangsu, China, 223300
Actively Recruiting
10
Nantong First People's Hospital
Nantong, Jiangsu, China, 226001
Actively Recruiting
11
Suqian People's Hospital
Suqian, Jiangsu, China, 223800
Actively Recruiting
12
Wuxi Third People's Hospital
Wuxi, Jiangsu, China, 214043
Actively Recruiting
13
Qinghai University Affiliated Hospital
Xining, Qinghai, China, 810001
Actively Recruiting
14
West China Longquan Hospital Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
15
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China, 830054
Actively Recruiting
16
Jinhua Municipal Central Hospital
Jinhua, Zhejiang, China, 321000
Actively Recruiting
17
Lishui Municipal Central Hospital
Lishui, Zhejiang, China, 323000
Actively Recruiting
Research Team
D
Dong Wu, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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