Actively Recruiting
Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis
Led by Johns Hopkins University · Updated on 2025-12-09
4874
Participants Needed
5
Research Sites
201 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research is being done to see if using oral tacrolimus before endoscopy, can prevent pancreatitis that may occur after ERCP (a type of gastrointestinal endoscopy).
CONDITIONS
Official Title
Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) at participating centers
- Age 18 years or older
- Provided informed consent to participate
You will not qualify if you...
- Unwilling or unable to provide consent
- Pregnancy
- Breastfeeding
- Chronic calcific pancreatitis
- ERCP performed for biliary stent exchange or removal
- ERCP in patients with prior biliary sphincterotomy without planned pancreatogram
- Biliary intervention in patients with pancreas divisum
- Standard contraindications to tacrolimus or NSAID use
- Current use of tacrolimus or immune modulators
- Chronic kidney disease with GFR less than 30 or acute kidney injury
- Absence of rectum
- Acute pancreatitis within 30 days before ERCP
- Pancreatic head malignancy
- Sphincter of Oddi dysfunction (Type 3)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
2
Asian Institute of Gastroenterology
Hyderabad, Andhra Pradesh, India, 500082
Actively Recruiting
3
Apollo Multispecialty Hospitals,
Kolkata, West Bengal, India, 700054
Not Yet Recruiting
4
Post Graduate Institute of Medical Education and Research
Chandigarh, India, 160012
Not Yet Recruiting
5
Singapore General Hospital
Singapore, Singapore, 169608
Not Yet Recruiting
Research Team
V
Venkata S. Akshintala, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here