Actively Recruiting
Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
Led by Masonic Cancer Center, University of Minnesota · Updated on 2026-02-03
78
Participants Needed
1
Research Sites
216 weeks
Total Duration
On this page
Sponsors
M
Masonic Cancer Center, University of Minnesota
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase II trial compares the effect of rectus sheath block with liposomal bupivacaine to thoracic epidural analgesia (TEA) on pain control in patients following surgical removal of all or part of the pancreas and duodenectomy (pancreatoduodenectomy). Administering long acting local anesthetics, such as liposomal bupivacaine, in between the muscle layers of the abdomen (rectus sheath block) may help with pain relief during and after surgery. TEA uses a needle to insert a flexible plastic catheter into the thoracic spine to administer anesthetic and pain medication, such as bupivacaine and hydromorphone, to treat pain in the thoracic and upper abdominal areas during and after surgery. Epidurals have been successfully used to treat pain after surgery, however, it does have a risk of low blood pressure which may limit the use in the thoracic approach. Rectus sheath blocks with liposomal bupivacaine may be as effective as TEA in reducing pain in patients following a pancreatoduodenectomy.
CONDITIONS
Official Title
Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients age 18 years or older
- Undergoing open pancreaticoduodenectomy at the University of Minnesota
You will not qualify if you...
- Contraindication to block placement such as coagulopathy, local anesthetic allergy, or infection
- Chronic opioid use of at least 30 milligram morphine equivalents daily for 3 or more weeks before surgery
- Inability to understand the quality of recovery survey due to intellectual barriers
- Patient refusal or opted out of research
- Pregnancy confirmed by medical record review
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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