Observational Study on Recurrence After Kidney Transplant in FSGS and Minimal Change Disease

What this Trial Is About

Researchers are investigating the course and recurrence of focal segmental glomerulosclerosis FSGS and minimal change disease MCD after kidney transplant. These conditions can lead to complications like reduced quality of life, edema, early graft loss, and mortality. The study aims to improve understanding of these diseases by collecting detailed information and biospecimens from patients who have had or will have a kidney transplant, enabling better research into their causes and outcomes. This observational study enrolls participants before or after transplant and also includes retrospective data from those transplanted since 2000. It collects clinical data, patient-reported information, and biospecimens such as urine, blood, saliva, and kidney tissue to create a biobank. Different enrollment options allow researchers to study the incidence, prevalence, and post-transplant progression of FSGS and MCD. Participants provide consent for data and biospecimen collection or are included through a waiver for existing data use. The study tracks outcomes like time to disease recurrence and graft failure over two years, along with measures of acute rejection, proteinuria changes, and delayed graft function. This comprehensive approach supports long-term monitoring and future research on these kidney diseases.

Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease