Actively Recruiting

Age: 18Years - 105Years
All Genders
NCT06777368

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Led by Medtronic Cardiovascular · Updated on 2026-02-12

225

Participants Needed

70

Research Sites

438 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).

CONDITIONS

Official Title

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Who Can Participate

Age: 18Years - 105Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Bioprosthetic valve failure of a transcatheter aortic valve (either Medtronic or Edwards) requiring redo Transcatheter Aortic Valve Replacement
Not Eligible

You will not qualify if you...

  • Bioprosthetic valve failure due solely to paravalvular regurgitation
  • Active endocarditis
  • Untreated acute valve thrombosis
  • Life expectancy less than 1 year
  • Participant is under the legal age of consent, legally incompetent, or otherwise vulnerable
  • Currently participating in another study that could affect this study's outcome

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 70 locations

1

University of Alabama at Birmingham

Birmingham, Alabama, United States, 35233

Actively Recruiting

2

Abrazo Arizona Heart Hospital

Phoenix, Arizona, United States, 85016

Actively Recruiting

3

Tucson Medical Center

Tucson, Arizona, United States, 85712

Actively Recruiting

4

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States, 90027

Actively Recruiting

5

Sutter Heatlh

Sacramento, California, United States, 95816

Actively Recruiting

6

Kaiser Permanente Northern California

Sacramento, California, United States, 95825

Actively Recruiting

7

Stanford Hospital & Clinics

Stanford, California, United States, 94305

Actively Recruiting

8

Los Robles Regional Medical Center

Thousand Oaks, California, United States, 91360

Actively Recruiting

9

Medical Center of the Rockies

Loveland, Colorado, United States, 80538

Actively Recruiting

10

Hartford Hospital

Hartford, Connecticut, United States, 06106

Actively Recruiting

11

Yale New Haven Hospital

New Haven, Connecticut, United States, 05610

Actively Recruiting

12

MedStar Washington Medical Center

Washington D.C., District of Columbia, United States, 20010

Actively Recruiting

13

Morton Plant Hospital

Clearwater, Florida, United States, 33756

Actively Recruiting

14

HealthPark Medical Center, Lee Memorial Health

Fort Myers, Florida, United States, 33908

Actively Recruiting

15

Orlando Health/Orlando Regional Medical Center

Orlando, Florida, United States, 32806

Actively Recruiting

16

Tampa General/USF

Tampa, Florida, United States, 33606

Actively Recruiting

17

Parkview Health

Fort Wayne, Indiana, United States, 46845

Actively Recruiting

18

Saint Vincent Heart Center of Indiana

Indianapolis, Indiana, United States, 46290

Actively Recruiting

19

MercyOne Iowa Heart Center

Des Moines, Iowa, United States, 50314

Actively Recruiting

20

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States, 52242

Actively Recruiting

21

The University of Kansas

Kansas City, Kansas, United States, 66103

Actively Recruiting

22

Ascension Via Christi St. Francis

Wichita, Kansas, United States, 67214

Actively Recruiting

23

Maine Medical Center

Portland, Maine, United States, 04102

Actively Recruiting

24

Medstar Union Memorial Hospital

Baltimore, Maryland, United States, 21218

Actively Recruiting

25

The Johns Hopkins Hospital

Baltimore, Maryland, United States, 21287

Actively Recruiting

26

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

Actively Recruiting

27

Brigham and Women's Hospital

Boston, Massachusetts, United States, 02135

Actively Recruiting

28

University of Michigan Health

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

29

Henry Ford Hospital

Detroit, Michigan, United States, 48202

Actively Recruiting

30

Corewell Health (Spectrum)

Grand Rapids, Michigan, United States, 49503

Actively Recruiting

31

Abbott Northwestern/Minneapolis Heart

Minneapolis, Minnesota, United States, 55407

Actively Recruiting

32

Mayo Clinic

Rochester, Minnesota, United States, 55905

Actively Recruiting

33

CentraCare Heart and Vascular Center

Saint Cloud, Minnesota, United States, 56303

Actively Recruiting

34

St. Luke's Hospital of Kansas City

Kansas City, Missouri, United States, 64111

Actively Recruiting

35

Providence Saint Patrick Hospital

Missoula, Montana, United States, 59802

Actively Recruiting

36

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States, 03756

Actively Recruiting

37

Catholic Medical Center

Manchester, New Hampshire, United States, 03102

Actively Recruiting

38

Jersey Shore University Medical Center

Neptune City, New Jersey, United States, 07753

Actively Recruiting

39

The Valley Hospital

Paramus, New Jersey, United States, 07652

Actively Recruiting

40

Buffalo General Medical Center

Buffalo, New York, United States, 14203

Actively Recruiting

41

Northwell Health

Manhasset, New York, United States, 11030

Actively Recruiting

42

NYU Langone Medical Center

New York, New York, United States, 10016

Actively Recruiting

43

Mount Sinai Hospital

New York, New York, United States, 10029

Actively Recruiting

44

Saint Francis Hospital

Roslyn, New York, United States, 11576

Actively Recruiting

45

Montefiore Medical Center

The Bronx, New York, United States, 10467

Actively Recruiting

46

Astrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

47

The Christ Hospital

Cincinnati, Ohio, United States, 45219

Actively Recruiting

48

University Hospitals of Cleveland Medical Center

Cleveland, Ohio, United States, 44106

Actively Recruiting

49

OhioHealth Riverside Methodist Hospital

Columbus, Ohio, United States, 43214

Actively Recruiting

50

Oklahoma Heart Hospital

Oklahoma City, Oklahoma, United States, 73120

Actively Recruiting

51

Providence Saint Vincent Medical Center

Portland, Oregon, United States, 97225

Actively Recruiting

52

Lehigh Valley Hospital

Allentown, Pennsylvania, United States, 18103

Actively Recruiting

53

UPMC Pinnacle

Mechanicsburg, Pennsylvania, United States, 17050

Actively Recruiting

54

Allegheny General Hospital

Pittsburgh, Pennsylvania, United States, 15212

Actively Recruiting

55

UPMC Presbyterian

Pittsburgh, Pennsylvania, United States, 15213

Actively Recruiting

56

Lankenau Medical Center

Wynnewood, Pennsylvania, United States, 19096

Actively Recruiting

57

TriStar Centennial Medical Center

Nashville, Tennessee, United States, 37203

Actively Recruiting

58

St. Thomas West Hospital

Nashville, Tennessee, United States, 37205

Actively Recruiting

59

Ascension Seton Medical Center Austin

Austin, Texas, United States, 78705

Actively Recruiting

60

Heart Hospital of Austin

Austin, Texas, United States, 78705

Actively Recruiting

61

Houston Methodist Hospital

Houston, Texas, United States, 77030

Actively Recruiting

62

University of Texas Health Science Center at Houston

Houston, Texas, United States, 77479

Actively Recruiting

63

Methodist Hospital

San Antonio, Texas, United States, 78229

Actively Recruiting

64

University of Vermont Medical Center

Burlington, Vermont, United States, 05401

Actively Recruiting

65

University of Virginia Medical Center

Charlottesville, Virginia, United States, 22908

Actively Recruiting

66

Inova Fairfax Hospital

Falls Church, Virginia, United States, 22042

Actively Recruiting

67

Sentara Norfolk General Hospital

Norfolk, Virginia, United States, 23507

Actively Recruiting

68

Providence Heart Institute (Providence Sacred Heart)

Spokane, Washington, United States, 99204

Actively Recruiting

69

Aurora St. Lukes Medical Center

Milwaukee, Wisconsin, United States, 53215

Actively Recruiting

70

Froedtert Hospital

Milwaukee, Wisconsin, United States, 53226

Actively Recruiting

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Research Team

R

RESTORE Study Clinical Team

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE | DecenTrialz