Actively Recruiting
Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma
Led by Mayo Clinic · Updated on 2026-04-22
112
Participants Needed
7
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase II trial compares the safety, side effects and effectiveness of reduced dose radiation therapy to standard of care dose radiation in treating patients with indolent non-Hodgkin lymphoma. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Standard of care radiation treatment for indolent non-Hodgkin lymphoma is usually delivered in 12 treatments. Studies have shown indolent lymphoma to be sensitive to radiation treatment, however, larger doses have higher rates of toxicities. A reduced radiation dose may be safe, tolerable and/or effective compared to standard of care radiation dose in treating patients with indolent non-Hodgkin lymphoma.
CONDITIONS
Official Title
Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histological confirmation of indolent B-cell lymphoma including follicular lymphoma (grade 1, 2, or 3A), marginal zone lymphoma (nodal or extranodal), or follicle center lymphoma
- Any stage of disease
- Initial, refractory, or relapsed disease with evidence of progression if relapse involves the treatment site
- Eastern Cooperative Oncology Group (ECOG) performance status of 3 or less
- Negative pregnancy test within 7 days prior to registration for persons of childbearing potential
- Ability to provide written informed consent
- Ability to complete questionnaires independently or with help
- Willingness to return for follow-up visits, including virtual visits
- Confirmation from a radiation oncologist that participation is suitable
You will not qualify if you...
- Pregnant women
- Nursing women
- Women of childbearing potential unwilling to use adequate contraception
- Diagnosis of T-cell lymphoma
- Currently receiving treatment for small or chronic lymphocytic lymphoma
- Grade 3B follicular lymphoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Actively Recruiting
3
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States, 56007
Actively Recruiting
4
Mayo Clinic Health System - Mankato
Mankato, Minnesota, United States, 56001
Actively Recruiting
5
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
6
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin, United States, 54701
Actively Recruiting
7
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, United States, 54601
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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