Actively Recruiting
Reduced Intensity Fludarabine and TBI Prior to Haplo-Identical Transplantation
Led by Northside Hospital, Inc. · Updated on 2026-04-16
20
Participants Needed
1
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial will evaluate the safety and efficacy of RIC HIDT transplant protocol following fludarabine and intermediate-dose TBI 800 cGy utilizing PBSC as the stem cell source.
CONDITIONS
Official Title
Reduced Intensity Fludarabine and TBI Prior to Haplo-Identical Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Availability of 3/6 to 5/6 matched related donor with a negative HLA-cross match in the host vs. graft direction willing to donate peripheral blood stem cells
- Karnofsky Performance Status (KPS) of 70% or higher
- Hematologic malignancy requiring allogeneic transplantation with high relapse risk after non-myeloablative or low intensity conditioning
You will not qualify if you...
- Poor cardiac function with left ventricular ejection fraction less than 45%
- Poor pulmonary function with FEV, FVC, or DLCO less than 60%
- Poor liver function with bilirubin 2.5 mg/dL or higher, or AST or ALT more than 3 times upper limit of normal
- Poor kidney function with creatinine clearance less than 40 mL/min
- HIV positive or active Hepatitis B or C infection
- Uncontrolled infection
- Pregnant female or unable to use adequate contraception
- Debilitating medical or psychiatric illness preventing informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Caitlin Guzowski
Atlanta, Georgia, United States, 30342
Actively Recruiting
Research Team
S
Stacey Brown
CONTACT
C
Caitlin Guzowski
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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